Novel 4-in-1 strategy to combat colon cancer, drug resistance and cancer relapse utilizing functionalized bioinspiring lignin nanoparticle
Language English Country United States Media print-electronic
Document type Journal Article
PubMed
30396459
DOI
10.1016/j.mehy.2018.09.003
PII: S0306-9877(18)30689-3
Knihovny.cz E-resources
- Keywords
- Antioxidants, CD44 receptors, Cancer relapse, Lignin, Multi drug resistance, Oxidative stress,
- MeSH
- Hyaluronan Receptors metabolism MeSH
- Antioxidants metabolism MeSH
- Apoptosis MeSH
- Biosimilar Pharmaceuticals chemistry MeSH
- Cell Cycle MeSH
- Caco-2 Cells MeSH
- Drug Resistance, Neoplasm * MeSH
- Rats MeSH
- Humans MeSH
- Lignin chemistry MeSH
- Neoplasm Recurrence, Local prevention & control MeSH
- DNA Mutational Analysis MeSH
- Colonic Neoplasms drug therapy pathology MeSH
- Nanoparticles chemistry MeSH
- DNA Mismatch Repair MeSH
- Oxidative Stress MeSH
- ATP Binding Cassette Transporter, Subfamily B metabolism MeSH
- Antineoplastic Agents chemistry MeSH
- Risk MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Hyaluronan Receptors MeSH
- Antioxidants MeSH
- Biosimilar Pharmaceuticals MeSH
- CD44 protein, human MeSH Browser
- Lignin MeSH
- ATP Binding Cassette Transporter, Subfamily B MeSH
- Antineoplastic Agents MeSH
Colon cancer is one of the fatal forms of cancer all round the world with a equal frequency of occurrence in both male and female population. Mutational changes and defects in APC (Adenomatous Polyposis Coli) and DNA mismatch repair genes accompanied by genetic chaos in oncogenic pathways leads to colon cancer. Intensive study on pathogenesis of colon cancer has been made to decipher the mechanisms underlying the development and progress of the disease so as to develop effective treatment. However, a complete therapeutic regimen is still not available for combating this deadly disease. Hurdles faced by chemotherapy include drug resistance due to P-glycoprotein transporters, untoward effects on normal cells, high cost, bio-burden of the therapy, and the most dreadful drawback is cancer relapse. The concept of cancer relapse is related to development of oxidative stress that causes cell apoptosis. If the level of oxidative stress is inadequate to cause apoptosis then it leads to cell dormancy which may revive post chemotherapy. This hypothesis aims to put forward a combinatorial approach that includes utilizing a cost effective, biocompatible and environmentally benign nanoparticulate carrier made up of lignin, loaded with anti-cancer agent and P-gp modulator, and functionalized with ligand for CD44 receptors that are over expressed on cancer cells. Antioxidant effect of lignin will overcome dormancy of cancer cells making it possible for cell cycle specific drugs to kill them and prevent relapse and active targeting will prevent untoward effects on normal cells. Thus a robust and wholesome formulation can be developed to combat colon cancer.
References provided by Crossref.org
Lignin for Bioeconomy: The Present and Future Role of Technical Lignin
An In Vitro Lung System to Assess the Proinflammatory Hazard of Carbon Nanotube Aerosols
The Self-Assembly of Lignin and Its Application in Nanoparticle Synthesis: A Short Review
