Galectin-Carbohydrate Interactions in Biomedicine and Biotechnology
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
30413271
DOI
10.1016/j.tibtech.2018.10.001
PII: S0167-7799(18)30264-6
Knihovny.cz E-resources
- Keywords
- Cancer, galectin, glycoconjugate, glycomimetic, neo-glycoprotein, thiodigalactoside,
- MeSH
- Biological Therapy methods MeSH
- Biomedical Research trends MeSH
- Biotechnology methods MeSH
- Molecular Targeted Therapy methods MeSH
- Galectins metabolism MeSH
- Carbohydrate Metabolism * MeSH
- Protein Binding MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Galectins MeSH
Cellular communication events are mediated by interactions between cell-surface sugars and lectins, which are carbohydrate-binding proteins. Galectins are β-galactosyl-binding lectins that bridge molecules by their sugar moieties, forming a signaling and adhesion network. Severe changes in glycosylation and galectin expression accompany major processes in oncogenesis, cardiovascular disorders, and other pathologies, making galectins attractive therapeutic targets. Here we discuss advanced strategies of chemo-enzymatic carbohydrate synthesis for creating lead glycomimetics and (neo-)glycoconjugates for galectin-1 and -3 targeting in biomedicine and biotechnology. We will describe the challenges and bottlenecks on the route into biomedical and biotechnological practice and present the first clinical candidates. The coming era will see an exciting translation of selective well-defined high-affinity galectin ligands from bench to bedside.
References provided by Crossref.org
Reversible Lectin Binding to Glycan-Functionalized Graphene
Cross-Linking Effects Dictate the Preference of Galectins to Bind LacNAc-Decorated HPMA Copolymers
The β-N-Acetylhexosaminidase in the Synthesis of Bioactive Glycans: Protein and Reaction Engineering
