Prognostic value of MRD in CLL patients with comorbidities receiving chlorambucil plus obinutuzumab or rituximab
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu klinické zkoušky, fáze III, dopisy, randomizované kontrolované studie, práce podpořená grantem
PubMed
30455380
PubMed Central
PMC6356981
DOI
10.1182/blood-2018-03-839688
PII: S0006-4971(20)42836-8
Knihovny.cz E-zdroje
- MeSH
- chlorambucil terapeutické užití MeSH
- chronická lymfatická leukemie diagnóza farmakoterapie epidemiologie MeSH
- dospělí MeSH
- humanizované monoklonální protilátky terapeutické užití MeSH
- komorbidita MeSH
- lidé středního věku MeSH
- lidé MeSH
- prognóza MeSH
- prospektivní studie MeSH
- protinádorové látky terapeutické užití MeSH
- protokoly protinádorové kombinované chemoterapie terapeutické užití MeSH
- reziduální nádor diagnóza farmakoterapie epidemiologie MeSH
- rituximab terapeutické užití MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- Publikační typ
- dopisy MeSH
- klinické zkoušky, fáze III MeSH
- práce podpořená grantem MeSH
- randomizované kontrolované studie MeSH
- Názvy látek
- chlorambucil MeSH
- humanizované monoklonální protilátky MeSH
- obinutuzumab MeSH Prohlížeč
- protinádorové látky MeSH
- rituximab MeSH
Publisher's Note: There is a Blood Commentary on this article in this issue.
Charles University Hospital Prague Czech Republic
Clinic 3 Hematology Oncology and Palliative Medicine University of Rostock Rostock Germany
Department of Hematology University of Schleswig Holstein Kiel Germany
Division of Hematology and Oncology Medical University of Innsbruck Innsbruck Austria
Internal Medicine 3 University of Ulm Ulm Germany
Kantonsspital Graubünden Chur Switzerland
Oncogeriatric Unit Department of Geriatric Medicine St Marien Hospital Cologne Germany
Pharma Development Oncology F Hoffmann La Roche Ltd Basel Switzerland
Pharma Development Oncology Roche Products Ltd Welwyn United Kingdom
Royal North Shore Hospital University of Sydney Sydney Australia
Zobrazit více v PubMed
Gribben JG. Chronic lymphocytic leukemia: planning for an aging population. Expert Rev Anticancer Ther. 2010;10(9):1389-1394. PubMed PMC
Barrientos JC. Management of chronic lymphocytic leukemia in the elderly. Cancer Contr. 2015;22(4 suppl):17-23. PubMed PMC
Evans SS, Clemmons AB. Obinutuzumab: A novel anti-CD20 monoclonal antibody for chronic lymphocytic leukemia. J Adv Pract Oncol. 2015;6(4):370-374. PubMed PMC
Mössner E, Brünker P, Moser S, et al. . Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell-mediated B-cell cytotoxicity. Blood. 2010;115(22):4393-4402. PubMed PMC
Owen CJ, Stewart DA. Obinutuzumab for the treatment of patients with previously untreated chronic lymphocytic leukemia: overview and perspective. Ther Adv Hematol. 2015;6(4):161-170. PubMed PMC
Eichhorst B, Robak T, Montserrat E, et al. ; ESMO Guidelines Committee. Chronic lymphocytic leukaemia: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2015;26(Suppl 5):v78-v84. PubMed
Wierda WG, Zelenetz AD, Gordon LI, et al. . NCCN Guidelines Insights: Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Version 1.2017. J Natl Compr Canc Netw. 2017;15(3):293-311. PubMed
Goede V, Fischer K, Busch R, et al. . Obinutuzumab plus chlorambucil in patients with CLL and coexisting conditions. N Engl J Med. 2014;370(12):1101-1110. PubMed
Goede V, Fischer K, Engelke A, et al. . Obinutuzumab as frontline treatment of chronic lymphocytic leukemia: updated results of the CLL11 study. Leukemia. 2015;29(7):1602-1604. PubMed
Goede V, Fischer K, Dyer MJS, et al. . Overall survival benefit of obinutuzumab over rituximab when combined with chlorambucil in patients with chronic lymphocytic leukemia and comorbidities: final survival analysis of the CLL11 study [abstract]. EHA Learning Center. 2018. Abstract S151.
Owen C, Christofides A, Johnson N, Lawrence T, MacDonald D, Ward C. Use of minimal residual disease assessment in the treatment of chronic lymphocytic leukemia. Leuk Lymphoma. 2017;58(12):2777-2785. PubMed
Dimier N, Delmar P, Ward C, et al. . A model for predicting effect of treatment on progression-free survival using MRD as a surrogate end point in CLL. Blood. 2018;131(9):955-962. PubMed
Wierda WG. Minimal residual disease provides treatment focus for next chronic lymphocytic leukemia advances. J Clin Oncol. 2016;34(31):3722-3723. PubMed
Böttcher S, Ritgen M, Fischer K, et al. . Minimal residual disease quantification is an independent predictor of progression-free and overall survival in chronic lymphocytic leukemia: a multivariate analysis from the randomized GCLLSG CLL8 trial. J Clin Oncol. 2012;30(9):980-988. PubMed
Kwok M, Rawstron AC, Varghese A, et al. . Minimal residual disease is an independent predictor for 10-year survival in CLL. Blood. 2016;128(24):2770-2773. PubMed
Kovacs G, Robrecht S, Fink AM, et al. . Minimal residual disease assessment improves prediction of outcome in patients with chronic lymphocytic leukemia (CLL) who achieve partial response: comprehensive analysis of two phase III studies of the German CLL Study Group. J Clin Oncol. 2016;34(31):3758-3765. PubMed
Hallek M, Cheson BD, Catovsky D, et al. ; International Workshop on Chronic Lymphocytic Leukemia. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood. 2008;111(12):5446-5456. PubMed PMC
Thompson PA, Wierda WG. Eliminating minimal residual disease as a therapeutic end point: working toward cure for patients with CLL. Blood. 2016;127(3):279-286. PubMed PMC
Böttcher S, Hallek M, Ritgen M, Kneba M. The role of minimal residual disease measurements in the therapy for CLL: is it ready for prime time? Hematol Oncol Clin North Am. 2013;27(2):267-288. PubMed
Strati P, Keating MJ, O’Brien SM, et al. . Eradication of bone marrow minimal residual disease may prompt early treatment discontinuation in CLL. Blood. 2014;123(24):3727-3732. PubMed PMC
Letestu R, Lévy V, Eclache V, et al. . Prognosis of Binet stage A chronic lymphocytic leukemia patients: the strength of routine parameters. Blood. 2010;116(22):4588-4590. PubMed
Damle RN, Wasil T, Fais F, et al. . Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood. 1999;94(6):1840-1847. PubMed
Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood. 1999;94(6):1848-1854. PubMed