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Imaging of Bronchial Pathology in Antibody Deficiency: Data from the European Chest CT Group

Schütz, Katharina
Author Schütz, Katharina Paediatric Immunology Unit, Department of Paediatric Pulmonology, Allergology and Neonatology, Hanover Medical School, Carl-Neuberg Str. 1, 30625, Hannover, Germany
Alecsandru, Diana
Author Alecsandru, Diana Primary Immunodeficiencies Unit, Pediatrics, Hospital 12 Octubre, Madrid, Spain Clinical Immunology, Royal Free Hospital, London, UK
Grimbacher, Bodo
Author Grimbacher, Bodo Clinical Immunology, Royal Free Hospital, London, UK Centre for Chronic Immunodeficiency, University Medical Center of Freiburg, Freiburg, Germany
Haddock, Jamanda
Author Haddock, Jamanda Radiology, Royal Free Hospital, London, UK
Bruining, Annemarie
Author Bruining, Annemarie Dutch Cancer Institute, Antoni van Leeuwenhoek Hospital, The Hague, The Netherlands
Driessen, Gertjan
Author Driessen, Gertjan Paediatric Immunology, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands Paediatrics, Juliana Children's Hospital/Haga Teaching Hospital, The Hague, The Netherlands
de Vries, Esther
Author de Vries, Esther Jeroen Bosch Academy, Jeroen Bosch Hospital, 's-Hertogenbosch, The Netherlands Tranzo, Tilburg University, Tilburg, The Netherlands
van Hagen, Peter M
Author van Hagen, Peter M Immunology and Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
Hartmann, Ieneke
Author Hartmann, Ieneke Department of Radiology, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands
Fraioli, Francesco
Author Fraioli, Francesco Radiology, Università degli Studi di Roma La Sapienza, Rome, Italy Institute of Nuclear Medicine, University College London, London, UK
Milito, Cinzia
Author Milito, Cinzia Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy
Mitrevski, Milica
Author Mitrevski, Milica Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy
Quinti, Isabella
Author Quinti, Isabella Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy
Serra, Goffredo
Author Serra, Goffredo Radiology, Università degli Studi di Roma La Sapienza, Rome, Italy
Kelleher, Peter
Author Kelleher, Peter Immunology Section Department of Medicine, Imperial College London, London, UK
Loebinger, Michael
Author Loebinger, Michael Department of Respiratory Medicine, Royal Brompton Hospital, London, UK
Litzman, Jiri
Author Litzman, Jiri Department of Clinical Immunology and Allergy, Faculty of Medicine, Masaryk University, St Anne's University Hospital, Brno, Czech Republic
Postranecka, Vera
Author Postranecka, Vera Department of Radiology, Faculty of Medicine, Masaryk University, St Anne's University Hospital, Brno, Czech Republic
Thon, Vojtech
Author Thon, Vojtech Department of Clinical Immunology and Allergy, Faculty of Medicine, Masaryk University, St Anne's University Hospital, Brno, Czech Republic RECETOX, Faculty of Science, Masaryk University, Brno, Czech Republic
Babar, Judith
Author Babar, Judith Radiology, Addenbrooke's Hospital, Cambridge, UK
Condliffe, Alison M
Author Condliffe, Alison M Radiology, Addenbrooke's Hospital, Cambridge, UK
Exley, Andrew
Author Exley, Andrew Immunology, Papworth Hospital, Cambridge, UK
Kumararatne, Dinakantha
Author Kumararatne, Dinakantha Immunology, Addenbrooke's Hospital, Cambridge, UK
Screaton, Nick
Author Screaton, Nick Radiology, Papworth Hospital, Cambridge, UK
Jones, Alison
Author Jones, Alison Paediatric Immunology, Great Ormond Street Hospital, London, UK
Bondioni, Maria P
Author Bondioni, Maria P Department of Radiology, University of Brescia, Brescia, Italy
Lougaris, Vassilios
Author Lougaris, Vassilios Pediatrics Clinic and Institute for Molecular Medicine A. Nocivelli, Department of Clinical and Experimental Sciences, University of Brescia and ASST-Spedali Civili of Brescia, Brescia, Italy
Plebani, Alessandro
Author Plebani, Alessandro Pediatrics Clinic and Institute for Molecular Medicine A. Nocivelli, Department of Clinical and Experimental Sciences, University of Brescia and ASST-Spedali Civili of Brescia, Brescia, Italy
Soresina, Annarosa
Author Soresina, Annarosa Pediatrics Clinic, ASST-Spedali Civili, Brescia, Italy
Sirignano, Cesare
Author Sirignano, Cesare Radiology, IBB-CNR University of Naples Federico II, Naples, Italy
Spadaro, Giuseppe
Author Spadaro, Giuseppe Immunology, University of Naples Federico II, Naples, Italy
Galal, Nermeen
Author Galal, Nermeen Paediatric University Hospital, Cairo, Egypt
Gonzalez-Granado, Luis I
Author Gonzalez-Granado, Luis I Primary Immunodeficiencies Unit, Pediatrics, Hospital 12 Octubre, Madrid, Spain
Dettmer, Sabine
Author Dettmer, Sabine Diagnostic Radiology, Hanover Medical School, Hanover, Germany
Stirling, Robert
Author Stirling, Robert Allergy, Immunology and Respiratory Medicine, The Alfred Hospital, Melbourne, Australia
Chapel, Helen
Author Chapel, Helen Primary Immunodeficiency Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK
Lucas, Mary
Author Lucas, Mary Primary Immunodeficiency Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK
Patel, Smita
Author Patel, Smita Primary Immunodeficiency Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK
Farber, Claire-Michele
Author Farber, Claire-Michele Immunology, Cliniques Universitaires de Bruxelles Hôpital Erasme, Brussels, Belgium
Meyts, Isabelle
Author Meyts, Isabelle Paediatric Immunology and Pulmonology, University Hospitals, Leuven, Belgium
Banerjee, Arpan K
Author Banerjee, Arpan K Radiology, Heartlands Hospital, Birmingham, UK
Hackett, Scott
Author Hackett, Scott Paediatric Immunology Department, Heartlands Hospital Birmingham, Birmingham, UK
Hurst, John R
Author Hurst, John R UCL Respiratory Medicine, University College London, London, UK
Warnatz, Klaus
Author Warnatz, Klaus Centre for Chronic Immunodeficiency, University Medical Center of Freiburg, Freiburg, Germany
Gathmann, Benjamin
Author Gathmann, Benjamin ESID Registry Working Party, University Hospital Freiburg, Freiburg, Germany
Baumann, Ulrich
Author Baumann, Ulrich Paediatric Immunology Unit, Department of Paediatric Pulmonology, Allergology and Neonatology, Hanover Medical School, Carl-Neuberg Str. 1, 30625, Hannover, Germany. Baumann.ulrich@mh-hannover.de
Chest CT in Antibody Deficiency Group
Author Chest CT in Antibody Deficiency Group

Journal of clinical immunology. 2019 Jan ; 39 (1) : 45-54. [epub] 20181213

J Clin Immunol
ISSN 1573-2592 | 0271-9142
Source

Language English Country Netherlands Media print-electronic

Document type Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't

Persistent link https://www.medvik.cz/link/pmid30547383

PubMed 30547383
DOI 10.1007/s10875-018-0577-9
PII: 10.1007/s10875-018-0577-9
Knihovny.cz E-resources

Keywords
CVID, Chest CT, bronchial pathology, bronchiectasis, primary antibody deficiency,
MeSH
Common Variable Immunodeficiency pathology MeSH
Bronchiectasis pathology MeSH
Bronchi pathology MeSH
Child MeSH
Adult MeSH
Thoracic Wall pathology MeSH
Infant MeSH
Humans MeSH
Adolescent MeSH
Young Adult MeSH
Tomography, X-Ray Computed methods MeSH
Child, Preschool MeSH
Aged MeSH
Spirometry methods MeSH
Immunologic Deficiency Syndromes pathology MeSH
Check Tag
Child MeSH
Adult MeSH
Infant MeSH
Humans MeSH
Adolescent MeSH
Young Adult MeSH
Male MeSH
Child, Preschool MeSH
Aged MeSH
Female MeSH
Publication type
Journal Article MeSH
Multicenter Study MeSH
Research Support, Non-U.S. Gov't MeSH

Studies of chest computed tomography (CT) in patients with primary antibody deficiency syndromes (ADS) suggest a broad range of bronchial pathology. However, there are as yet no multicentre studies to assess the variety of bronchial pathology in this patient group. One of the underlying reasons is the lack of a consensus methodology, a prerequisite to jointly document chest CT findings. We aimed to establish an international platform for the evaluation of bronchial pathology as assessed by chest CT and to describe the range of bronchial pathologies in patients with antibody deficiency. Ffteen immunodeficiency centres from 9 countries evaluated chest CT scans of patients with ADS using a predefined list of potential findings including an extent score for bronchiectasis. Data of 282 patients with ADS were collected. Patients with common variable immunodeficiency disorders (CVID) comprised the largest subgroup (232 patients, 82.3%). Eighty percent of CVID patients had radiological evidence of bronchial pathology including bronchiectasis in 61%, bronchial wall thickening in 44% and mucus plugging in 29%. Bronchiectasis was detected in 44% of CVID patients aged less than 20 years. Cough was a better predictor for bronchiectasis than spirometry values. Delay of diagnosis as well as duration of disease correlated positively with presence of bronchiectasis. The use of consensus diagnostic criteria and a pre-defined list of bronchial pathologies allows for comparison of chest CT data in multicentre studies. Our data suggest a high prevalence of bronchial pathology in CVID due to late diagnosis or duration of disease.

Allergy Immunology and Respiratory Medicine The Alfred Hospital Melbourne Australia

Centre for Chronic Immunodeficiency University Medical Center of Freiburg Freiburg Germany

Clinical Immunology Royal Free Hospital London UK

Department of Clinical Immunology and Allergy Faculty of Medicine Masaryk University St Anne's University Hospital Brno Czech Republic

Department of Molecular Medicine Sapienza University of Rome Rome Italy

Department of Radiology Erasmus MC Sophia Children's Hospital Rotterdam The Netherlands

Department of Radiology Faculty of Medicine Masaryk University St Anne's University Hospital Brno Czech Republic

Department of Radiology University of Brescia Brescia Italy

Department of Respiratory Medicine Royal Brompton Hospital London UK

Diagnostic Radiology Hanover Medical School Hanover Germany

Dutch Cancer Institute Antoni van Leeuwenhoek Hospital The Hague The Netherlands

ESID Registry Working Party University Hospital Freiburg Freiburg Germany