Evolution of Cancer Progression in the Context of Darwinism
Language English Country Greece Media print
Document type Journal Article, Review
PubMed
30591435
DOI
10.21873/anticanres.13074
PII: 39/1/1
Knihovny.cz E-resources
- Keywords
- Tumor microenvironment, cancer ecology, prognosis, regeneration, review, species development, stem cells, wound healing,
- MeSH
- Biological Evolution * MeSH
- Precision Medicine * MeSH
- Neoplasm Invasiveness genetics MeSH
- Humans MeSH
- Tumor Microenvironment genetics MeSH
- Neoplasms genetics MeSH
- Cell Proliferation genetics MeSH
- Selection, Genetic genetics MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
Our review compares evolution of cancer in the human body to the origin of new species from a common ancestor organism with respect to the theory of Charles Darwin. Moreover, the functional role of the tumor microenvironment as a selective pressure actively participating in cancer progression is also demonstrated. Evolutionary aspects of tumor growth and invasion from the point of view of modern therapeutic challenges and opportunities in precision personalized medicine are also discussed.
BIOCEV 1st Faculty of Medicine Charles University Vestec Czech Republic
Department of Pharmacognosy and Botany Comenius University Bratislava Slovak Republic
Department of Pharmacology Faculty of Medicine Košice Slovak Republic
Institute of Anatomy 1st Faculty of Medicine Charles University Prague Czech Republic
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