BACKGROUND: In randomized clinical trials, mechanical thrombectomy (MT) was proved to be a highly effective treatment of acute ischemic stroke which improved clinical outcomes. Some of the trials used automated computed tomography perfusion (CTP) analysis for selection of participants. We present a single-center experience with CTP selection and comparison with CTP trials. METHODS: Data of consecutive MT patients (from January 2016 to December 2017) were retrospectively reviewed. All patients with multiphase CT angiography confirmed the presence of anterior circulation large vessel occlusion/s in the intracranial internal carotid artery and/or middle cerebral artery (M1 or M2) and with admission brain CTP analyzed by RAPID software were included into the analysis. RESULTS: Sixty-two patients fulfilled the inclusion criteria (mean age was 70.1 ± 13.6 years, females 48.5%). At baseline, National Institutes of Health Stroke Scale score was 16 (IQR = 13-20), Alberta Stroke Program Early CT Score (ASPECTS) was 8 (IQR = 7-9), CTP core volume was 20 mL (IQR = 2-36), and CTP penumbra volume was 145.5 mL (IQR = 107-184). Time from stroke onset to imaging was 1 hour 32 minutes, time from stroke onset to reperfusion was 3 hours 50 minutes, and median time from CT to reperfusion was 1 hour 56 minutes. Modified thrombolysis in cerebral infarction 2b/3 was achieved in 42 patients (67.7%). Twenty-three patients (37%) had modified Rankin scale 0-2 at 90 days. CONCLUSIONS: Our analysis of CTP-selected patients for MT supports clinical applicability of automated CTP analysis into everyday clinical practice.

Department of Medical Imaging St Anne´s University Hospital and Faculty of Medicine Masaryk University Brno Czech Republic

Department of Medical Imaging St Anne´s University Hospital and Faculty of Medicine Masaryk University Brno Czech Republic; International Clinical Research Centre Stroke Research Program St Anne´s University Hospital Brno Czech Republic

Division of Interventional Neuroradiology David Geffen School of Medicine University of California Los Angeles California

Institute of Biostatistics and Analyses Faculty of Medicine Masaryk University Brno Czech Republic

International Clinical Research Centre Stroke Research Program St Anne´s University Hospital Brno Czech Republic; Departments of Clinical Neurosciences Calgary Stroke Program Cumming School of Medicine University of Calgary Calgary Canada; Department of Neurology St Anne´s University Hospital and Faculty of Medicine Masaryk University Brno Czech Republic

Citace poskytuje Crossref.org

Effects of reperfusion grade and reperfusion strategy on the clinical outcome: Insights from ESCAPE-NA1 trial