• This record comes from PubMed

Haem Biology in Metazoan Parasites - 'The Bright Side of Haem'

. 2019 Mar ; 35 (3) : 213-225. [epub] 20190124

Language English Country England, Great Britain Media print-electronic

Document type Journal Article, Research Support, Non-U.S. Gov't, Review

Links

PubMed 30686614
DOI 10.1016/j.pt.2019.01.001
PII: S1471-4922(19)30001-7
Knihovny.cz E-resources

Traditionally, host haem has been recognized as a cytotoxic molecule that parasites need to eliminate or detoxify in order to survive. However, recent evidence indicates that some lineages of parasites have lost genes that encode enzymes involved specifically in endogenous haem biosynthesis. Such lineages thus need to acquire and utilize haem originating from their host animal, making it an indispensable molecule for their survival and reproduction. In multicellular parasites, host haem needs to be systemically distributed throughout their bodies to meet the haem demands in all cell and tissue types. Host haem also gets deposited in parasite eggs, enabling embryogenesis and reproduction. Clearly, a better understanding of haem biology in multicellular parasites should elucidate organismal adaptations to obligatory blood-feeding.

References provided by Crossref.org

Find record

Citation metrics

Loading data ...

Archiving options

Loading data ...