Haem Biology in Metazoan Parasites - 'The Bright Side of Haem'
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
30686614
DOI
10.1016/j.pt.2019.01.001
PII: S1471-4922(19)30001-7
Knihovny.cz E-resources
- Keywords
- blood-feeding, haem auxotrophy, iron, metazoan parasites, nematodes, ticks,
- MeSH
- Adaptation, Physiological MeSH
- Heme biosynthesis genetics metabolism MeSH
- Host-Parasite Interactions physiology MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Heme MeSH
Traditionally, host haem has been recognized as a cytotoxic molecule that parasites need to eliminate or detoxify in order to survive. However, recent evidence indicates that some lineages of parasites have lost genes that encode enzymes involved specifically in endogenous haem biosynthesis. Such lineages thus need to acquire and utilize haem originating from their host animal, making it an indispensable molecule for their survival and reproduction. In multicellular parasites, host haem needs to be systemically distributed throughout their bodies to meet the haem demands in all cell and tissue types. Host haem also gets deposited in parasite eggs, enabling embryogenesis and reproduction. Clearly, a better understanding of haem biology in multicellular parasites should elucidate organismal adaptations to obligatory blood-feeding.
References provided by Crossref.org
Genome sequences of four Ixodes species expands understanding of tick evolution
Insight Into the Dynamics of the Ixodes ricinus Nymphal Midgut Proteome
Babesia, Theileria, Plasmodium and Hemoglobin
Haem-responsive gene transporter enables mobilization of host haem in ticks