Neural Scaffolding as the Foundation for Stable Performance of Aging Cerebellum
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články
Grantová podpora
#691110
Horizon 2020 Framework Programme
PubMed
30827012
DOI
10.1007/s12311-019-01015-7
PII: 10.1007/s12311-019-01015-7
Knihovny.cz E-zdroje
- Klíčová slova
- Cerebellar aging, Functional connectivity, Voxel-based morphometry, fMRI,
- MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mozeček patologie fyziologie MeSH
- pohybová aktivita fyziologie MeSH
- pozornost fyziologie MeSH
- průřezové studie MeSH
- senioři MeSH
- stárnutí patologie fyziologie MeSH
- zdravé stárnutí patologie fyziologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
Although recently conceptualized as a neural node essential for a vast spectrum of associative and cognitive processes, the cerebellum has largely eluded attention in the research of aging, where it is marginalized mainly to structural analyses. In the current cross-sectional study of 67 healthy subjects of various ages (20 to 76 years), we sought to provide a comprehensive, multimodal account of age-related changes in the cerebellum during predictive motor timing, which was previously shown to engage this structure. We combined behavioral assessments of performance with functional MRI and voxel-based morphometry using an advanced method to avoid cerebellar deformation and registration imprecisions inherent to the standard processing at the whole-brain level. Higher age was surprisingly associated with stable behavioral performance during predictive motor timing, despite the massive decrease of infratentorial gray matter volume of a far higher extent than in the supratentorial region, affecting mainly the posterior cerebellar lobe. Nonetheless, this very area showed extensive hyperactivation directly correlated with age. The same region had decreased connectivity with the left caudate and increased connectivity with the left fusiform gyrus, the right pallidum, the hippocampus, and the lingual gyrus. Hence, we propose to extend the scaffolding theory of aging, previously limited mainly to the frontal cortices, to include also the cerebellum, which is likewise suffering from atrophy to a far greater extent than the rest of the brain and is similarly counteracting it by bilateral hyperactivation.
Center for Magnetic Resonance Research University of Minnesota Minneapolis MN USA
Department of Neurology School of Medicine University of Minnesota Minneapolis MN USA
Department of Psychiatry Université de Montréal Montréal Québec Canada
Zobrazit více v PubMed
Neuropsychology. 2000 Jul;14(3):341-52 PubMed
Curr Biol. 2000 Oct 19;10(20):R731-5 PubMed
Neuroimage. 2001 Jan;13(1):161-75 PubMed
AJNR Am J Neuroradiol. 2001 Jun-Jul;22(6):1161-7 PubMed
Neurobiol Aging. 2001 Jul-Aug;22(4):581-94 PubMed
J Neuroimaging. 2001 Oct;11(4):393-400 PubMed
Neuroimage. 2002 Jan;15(1):273-89 PubMed
Neurology. 2002 Feb 26;58(4):630-5 PubMed
Psychol Aging. 2002 Mar;17(1):85-100 PubMed
Brain. 2003 Apr;126(Pt 4):873-88 PubMed
Neuroimage. 2003 Jul;19(3):555-64 PubMed
J Physiol. 2005 Jan 15;562(Pt 2):605-15 PubMed
Neuroimage. 2005 May 1;25(4):1325-35 PubMed
Neurobiol Aging. 2005 Oct;26(9):1261-70; discussion 1275-8 PubMed
Neuroimage. 2006 Sep;32(3):1250-6 PubMed
Neuroimage. 2006 Oct 15;33(1):127-38 PubMed
Exp Brain Res. 2007 Jun;180(2):355-65 PubMed
Neuroimage. 2007 Jul 15;36(4):1263-76 PubMed
Neuroimage. 2009 Jan 15;44(2):489-501 PubMed
Annu Rev Psychol. 2009;60:173-96 PubMed
Neuroimage. 2009 May 15;46(1):39-46 PubMed
Neurosci Biobehav Rev. 2010 Apr;34(5):721-33 PubMed
J Int Neuropsychol Soc. 2010 Sep;16(5):754-60 PubMed
Cerebellum. 2011 Jun;10(2):233-44 PubMed
Cerebellum. 2012 Jun;11(2):352-65 PubMed
J Neurophysiol. 2011 Nov;106(5):2322-45 PubMed
Neurosci Lett. 2011 Oct 17;504(1):68-72 PubMed
Neurosci Biobehav Rev. 2013 Mar;37(3):384-400 PubMed
Cerebellum. 2013 Oct;12(5):721-37 PubMed
J Neuroimaging. 2013 Oct;23(4):452-62 PubMed
Neuroimage. 2013 Dec;83:103-19 PubMed
Neural Plast. 2013;2013:908741 PubMed
Neurosci Biobehav Rev. 2014 May;42:193-207 PubMed
Science. 2014 Oct 31;346(6209):587-91 PubMed
Cold Spring Harb Perspect Biol. 2015 Sep 01;7(9):a021683 PubMed
Cerebellum. 2016 Dec;15(6):774-780 PubMed
Neuroimage. 2016 Apr 1;129:389-400 PubMed
Neural Plast. 2016;2016:2073454 PubMed
Tremor Other Hyperkinet Mov (N Y). 2016 Jun 23;6:376 PubMed
Mov Disord. 2017 May;32(5):757-768 PubMed
J Pharmacokinet Biopharm. 1987 Dec;15(6):657-80 PubMed
Neuropsychologia. 1971 Mar;9(1):97-113 PubMed
Acta Psychol (Amst). 1969;30:3-15 PubMed
Neuroimage. 1997 Oct;6(3):218-29 PubMed
Brain. 1998 Apr;121 ( Pt 4):561-79 PubMed
Consensus Paper: Cerebellum and Ageing
Utility of quantitative MRI metrics in brain ageing research