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PubMed

Záznam pochází z PubMed

Neural Scaffolding as the Foundation for Stable Performance of Aging Cerebellum

Filip, Pavel
Autor Filip, Pavel ORCID Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, USA. pvlfilip@gmail.com First Department of Neurology, Faculty of Medicine, University Hospital of St. Anne, Masaryk University, Brno, Czech Republic. pvlfilip@gmail.com
Gallea, Cécile
Autor Gallea, Cécile Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche, Sorbonne Université UMR S1127, Inserm U1127, CNRS 7225, Paris, France
Lehéricy, Stéphane
Autor Lehéricy, Stéphane Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche, Sorbonne Université UMR S1127, Inserm U1127, CNRS 7225, Paris, France
Lungu, Ovidiu
Autor Lungu, Ovidiu Department of Psychiatry, Université de Montréal, Montréal, Québec, Canada Functional Neuroimaging Unit, Research Center of the Geriatric Institute affiliated with the Université de Montréal, Montréal, Québec, Canada
Bareš, Martin
Autor Bareš, Martin First Department of Neurology, Faculty of Medicine, University Hospital of St. Anne, Masaryk University, Brno, Czech Republic Department of Neurology, School of Medicine, University of Minnesota, Minneapolis, MN, USA

Cerebellum (London, England). 2019 Jun ; 18 (3) : 500-510.

Cerebellum
ISSN 1473-4230 | 1473-4222
Zdroj

Jazyk angličtina Země Spojené státy americké Médium print

Typ dokumentu časopisecké články

Perzistentní odkaz https://www.medvik.cz/link/pmid30827012

Grantová podpora
#691110 Horizon 2020 Framework Programme

PubMed 30827012
DOI 10.1007/s12311-019-01015-7
PII: 10.1007/s12311-019-01015-7
Knihovny.cz E-zdroje

Klíčová slova
Cerebellar aging, Functional connectivity, Voxel-based morphometry, fMRI,
MeSH
dospělí MeSH
lidé středního věku MeSH
lidé MeSH
mladý dospělý MeSH
mozeček patologie fyziologie MeSH
pohybová aktivita fyziologie MeSH
pozornost fyziologie MeSH
průřezové studie MeSH
senioři MeSH
stárnutí patologie fyziologie MeSH
zdravé stárnutí patologie fyziologie MeSH
Check Tag
dospělí MeSH
lidé středního věku MeSH
lidé MeSH
mladý dospělý MeSH
mužské pohlaví MeSH
senioři MeSH
ženské pohlaví MeSH
Publikační typ
časopisecké články MeSH

Although recently conceptualized as a neural node essential for a vast spectrum of associative and cognitive processes, the cerebellum has largely eluded attention in the research of aging, where it is marginalized mainly to structural analyses. In the current cross-sectional study of 67 healthy subjects of various ages (20 to 76 years), we sought to provide a comprehensive, multimodal account of age-related changes in the cerebellum during predictive motor timing, which was previously shown to engage this structure. We combined behavioral assessments of performance with functional MRI and voxel-based morphometry using an advanced method to avoid cerebellar deformation and registration imprecisions inherent to the standard processing at the whole-brain level. Higher age was surprisingly associated with stable behavioral performance during predictive motor timing, despite the massive decrease of infratentorial gray matter volume of a far higher extent than in the supratentorial region, affecting mainly the posterior cerebellar lobe. Nonetheless, this very area showed extensive hyperactivation directly correlated with age. The same region had decreased connectivity with the left caudate and increased connectivity with the left fusiform gyrus, the right pallidum, the hippocampus, and the lingual gyrus. Hence, we propose to extend the scaffolding theory of aging, previously limited mainly to the frontal cortices, to include also the cerebellum, which is likewise suffering from atrophy to a far greater extent than the rest of the brain and is similarly counteracting it by bilateral hyperactivation.

1st Department of Neurology Faculty of Medicine University Hospital of St Anne Masaryk University Brno Czech Republic

Center for Magnetic Resonance Research University of Minnesota Minneapolis MN USA

Department of Neurology School of Medicine University of Minnesota Minneapolis MN USA

Department of Psychiatry Université de Montréal Montréal Québec Canada

Functional Neuroimaging Unit Research Center of the Geriatric Institute affiliated with the Université de Montréal Montréal Québec Canada

Institut du Cerveau et de la Moelle épinière ICM Centre de NeuroImagerie de Recherche Sorbonne Université UMR S1127 Inserm U1127 CNRS 7225 Paris France

Zobrazit více v PubMed

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