Balkan Endemic Nephropathy and the Causative Role of Aristolochic Acid
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
Grantová podpora
101126/Z/13/Z
Wellcome Trust - United Kingdom
101126/B/13/Z
Wellcome Trust - United Kingdom
PubMed
31054628
DOI
10.1016/j.semnephrol.2019.02.007
PII: S0270-9295(19)30013-0
Knihovny.cz E-zdroje
- Klíčová slova
- Aristolochia species, Balkan endemic nephropathy, aristolochic acid, aristolochic acid nephropathy, upper tract urothelial carcinoma,
- MeSH
- adukty DNA MeSH
- Aristolochia MeSH
- balkánská nefropatie chemicky indukované diagnóza patologie terapie MeSH
- karcinogeny toxicita MeSH
- karcinom z přechodných buněk chemicky indukované MeSH
- kyseliny aristolochové toxicita MeSH
- lidé MeSH
- nádory ledvin chemicky indukované MeSH
- nádory močovodu chemicky indukované MeSH
- plošný screening MeSH
- vystavení vlivu životního prostředí škodlivé účinky MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- adukty DNA MeSH
- aristolochic acid I MeSH Prohlížeč
- karcinogeny MeSH
- kyseliny aristolochové MeSH
Balkan endemic nephropathy is a chronic tubulointerstitial disease with insidious onset, slowly progressing to end-stage renal disease and frequently associated with urothelial carcinoma of the upper urinary tract (UTUC). It was described in South-East Europe at the Balkan peninsula in rural areas around tributaries of the Danube River. After decades of intensive investigation, the causative factor was identified as the environmental phytotoxin aristolochic acid (AA) contained in Aristolochia clematitis, a common plant growing in wheat fields that was ingested through home-baked bread. AA initially was involved in the outbreak of cases of rapidly progressive renal fibrosis reported in Belgium after intake of root extracts of Aristolochia fangchi imported from China. A high prevalence of UTUC was found in these patients. The common molecular link between Balkan and Belgian nephropathy cases was the detection of aristolactam-DNA adducts in renal tissue and UTUC. These adducts are not only biomarkers of prior exposure to AA, but they also trigger urothelial malignancy by inducing specific mutations (A:T to T:A transversion) in critical genes of carcinogenesis, including the tumor-suppressor TP53. Such mutational signatures are found in other cases worldwide, particularly in Taiwan, highlighting the general public health issue of AA exposure by traditional phytotherapies.
Clinical Centre Serbia Belgrade Serbia
Department of Biochemistry Faculty of Science Charles University Prague 2 Czech Republic
Nephrology Department Erasme Hospital Université Libre de Bruxelles Brussels Belgium
Citace poskytuje Crossref.org
The impact of p53 on aristolochic acid I-induced nephrotoxicity and DNA damage in vivo and in vitro