Diet Rich in Animal Protein Promotes Pro-inflammatory Macrophage Response and Exacerbates Colitis in Mice
Jazyk angličtina Země Švýcarsko Médium electronic-ecollection
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
31105710
PubMed Central
PMC6497971
DOI
10.3389/fimmu.2019.00919
Knihovny.cz E-zdroje
- Klíčová slova
- colitis, dietary protein, germ-free, macrophage, microbiota,
- MeSH
- adaptivní imunita imunologie MeSH
- buňky Th17 imunologie metabolismus MeSH
- dieta škodlivé účinky MeSH
- dietní proteiny aplikace a dávkování škodlivé účinky MeSH
- DNA vazebné proteiny metabolismus MeSH
- kolitida imunologie metabolismus patologie MeSH
- kolon imunologie metabolismus patologie MeSH
- makrofágy imunologie metabolismus patologie MeSH
- modely nemocí na zvířatech MeSH
- monocyty imunologie metabolismus patologie MeSH
- myši inbrední BALB C MeSH
- myši knockoutované MeSH
- myši MeSH
- regulační T-lymfocyty imunologie metabolismus MeSH
- střeva imunologie patologie MeSH
- střevní mikroflóra imunologie fyziologie MeSH
- zánět imunologie metabolismus patologie MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- dietní proteiny MeSH
- DNA vazebné proteiny MeSH
Diet is a major factor determining gut microbiota composition and perturbances in this complex ecosystem are associated with the inflammatory bowel disease (IBD). Here, we used gnotobiotic approach to analyze, how interaction between diet rich in proteins and gut microbiota influences the sensitivity to intestinal inflammation in murine model of ulcerative colitis. We found that diet rich in animal protein (aHPD) exacerbates acute dextran sulfate sodium (DSS)-induced colitis while diet rich in plant protein (pHPD) does not. The deleterious effect of aHPD was also apparent in chronic DSS colitis and was associated with distinct changes in gut bacteria and fungi. Therefore, we induced acute DSS-colitis in germ-free mice and transferred gut microbiota from aCD or aHPD fed mice to find that this effect requires presence of microbes and aHPD at the same time. The aHPD did not change the number of regulatory T cells or Th17 cells and still worsened the colitis in immuno-deficient RAG2 knock-out mice suggesting that this effect was not dependent on adaptive immunity. The pro-inflammatory effect of aHPD was, however, abrogated when splenic macrophages were depleted with clodronate liposomes. This treatment prevented aHPD induced increase in colonic Ly-6Chigh pro-inflammatory monocytes, but the ratio of resident Ly-6C-/low macrophages was not changed. These data show that the interactions between dietary protein of animal origin and gut microbiota increase sensitivity to intestinal inflammation by promoting pro-inflammatory response of monocytes.
Department of Pharmacology Institute of Experimental Medicine of the CAS v v i Prague Czechia
Faculty of Applied Sciences University of West Bohemia Pilsen Czechia
Laboratory of Gnotobiology Institute of Microbiology of the CAS v v i Nový Hrádek Czechia
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Healthy microbiome - a mere idea or a sound concept?