Comorbidities of early-onset temporal epilepsy: Cognitive, social, emotional, and morphologic dimensions
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
31278943
DOI
10.1016/j.expneurol.2019.113005
PII: S0014-4886(18)30638-1
Knihovny.cz E-resources
- Keywords
- Anxiety, Cognition, Depression, Epilepsy, Exploratory behavior, Hippocampus, Pilocarpine, Rats, Spatial learning, Status epilepticus,
- MeSH
- Maze Learning physiology MeSH
- Behavior, Animal physiology MeSH
- Epilepsy, Temporal Lobe pathology physiopathology MeSH
- Cognition Disorders pathology physiopathology MeSH
- Rats MeSH
- Brain pathology physiopathology MeSH
- Rats, Wistar MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Epilepsy, the most common neurologic disorder in childhood, is associated with a subset of psychiatric dysfunctions, including cognitive deficits, and alterations in emotionality (e.g., anxiety and depression) and social functioning. In the present study, we evaluated an integrative set of behavioral responses, including cognitive/socio-cognitive and emotional dimensions, using a number of behavioral paradigms in the LiCl/pilocarpine model of status epilepticus (SE) in rats. The aims of the study were to examine whether SE affects: 1) non-associative learning (habituation of exploratory behavior); 2) investigatory response to an indifferent stimulus object; 3) sociability/social novelty preference; 4) social recognition or discrimination; and 4) short- and long-term memory in the Morris water maze (MWM). Finally, we investigated the morphology of key brain structures involved in the examined behavioral dysfunctions. SE did not affect habituation to an open-field arena in juvenile (P25), adolescent (P32), or adult (P80) rats. SE rats spent less time in the central part of the arena. SE adolescent rats (P32) displayed a higher number of rearings with a shorter duration. SE rats displayed a markedly attenuated investigatory response to an indifferent stimulus object. SE rats in all age groups demonstrated pronounced deficits in sociability and the preference for social novelty. In addition, SE rats spent a reduced amount of time investigating a juvenile rat upon first exposure. After 30 min re-exposure together with an additional, novel juvenile, the SE rats spent equal time investigating both juveniles. In the MWM task, acquisition was unimpaired but there was a deficit in delayed memory retention after 10 days. SE did not affect cognitive flexibility expressed by reversal learning. Together, these findings suggest that early-life SE leads to alterations in emotional/anxiety-related behavior and affects sociability/preference for social novelty and social discrimination. Early-life SE did not alter acquisition of spatial learning, but it impaired delayed retention. Using Fluoro Jade B staining performed 24 h after SE revealed apparent neurodegeneration in the dorsal hippocampus, mediodorsal thalamic nucleus and medial amygdala, brain areas that are critically involved in network underlying emotional behavior and cognitive functions.
References provided by Crossref.org
A new two-hit animal model for schizophrenia research: Consequences on social behavior
Epilepsy Research in the Institute of Physiology of the Czech Academy of Sciences in Prague
The outcome of early life status epilepticus-lessons from laboratory animals
Infantile status epilepticus disrupts myelin development
Epilepsy miRNA Profile Depends on the Age of Onset in Humans and Rats
