Our aim was to compare the protective efficacy of two different formulations of methylprednisolone in T-2 toxin-induced cardiomyopathy. Methylprednisolone (soluble form, Lemod-solu® and/or depot form, Lemod-depo®, a total single dose of 40 mg/kg im) was given immediately after T-2 toxin (1 LD50 0.23 mg/kg sc). The myocardial tissue samples were examinated by using histopathology, semiquantitative and imaging analyses on day 1, 7, 14, 21, 28 and 60 of the study. Therapeutic application of Lemod-solu® significantly decreased the intensity of myocardial degeneration and haemorrhages, distribution of glycogen granules in the endo- and perimysium, a total number of mast cells and the degree of their degranulation was in correlation with the reversible heart structural lesions (p < 0.01 vs. T-2 toxin). These changes were completely abolished by the therapeutic use of Lemod-solu® plus Lemod-depo® (p < 0.001 vs. T-2 toxin). Our results show that a significant cardioprotective efficacy of methylprednisolone is mediated by its anti-inflammatory activity.

College of Life Science Yangtze University 1 Nanhuan Road 434023 Jingzhou Hubei China; Department of Chemistry Faculty of Science University of Hradec Kralove Rokitanského 62 500 03 Hradec Králové Czechia

Department of Chemistry Faculty of Science University of Hradec Kralove Rokitanského 62 500 03 Hradec Králové Czechia

Department of Chemistry Faculty of Science University of Hradec Kralove Rokitanského 62 500 03 Hradec Králové Czechia; Malaysia Japan International Institute of Technology University Teknologi Malaysia Jalan Sultan Yahya Petra 54100 Kuala Lumpur Malaysia

National Poison Control Centre Military Medical Academy 17 Crnotravska St 11000 Belgrade Serbia; Medical Faculty of the Military Medical Academy University of Defence 1 Pavla Jurišića Šturma St 11000 Belgrade Serbia; Department of Chemistry Faculty of Science University of Hradec Kralove Rokitanského 62 500 03 Hradec Králové Czechia

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