Complex karyotype as a predictor of high-risk chronic lymphocytic leukemia: A single center experience over 12 years
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
31476701
DOI
10.1016/j.leukres.2019.106218
PII: S0145-2126(19)30163-8
Knihovny.cz E-resources
- Keywords
- ATM, Chronic lymphocytic leukemia (CLL), Complex karyotype, Cytogenetics, TP53,
- MeSH
- Abnormal Karyotype * MeSH
- Chromosome Aberrations * MeSH
- Leukemia, Lymphocytic, Chronic, B-Cell diagnosis genetics mortality therapy MeSH
- Adult MeSH
- Genetic Predisposition to Disease * MeSH
- Genetic Association Studies * MeSH
- In Situ Hybridization, Fluorescence MeSH
- Kaplan-Meier Estimate MeSH
- Middle Aged MeSH
- Humans MeSH
- Disease Management MeSH
- Mutation MeSH
- Biomarkers, Tumor MeSH
- Follow-Up Studies MeSH
- Prognosis MeSH
- Risk Factors MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Comparative Genomic Hybridization MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Biomarkers, Tumor MeSH
OBJECTIVES: A complex karyotype (CK) is considered a poor prognostic marker in chronic lymphocytic leukemia (CLL). METHODS: The study analyzed 644 untreated CLL patients (pts) using conventional/molecular cytogenetics to reveal the presence of a CK and its composition and to assess its predictive value. The mutational status ofTP53 was detected by next generation sequencing. RESULTS: A CK was detected in 79 pts (12.3%). Patients with a CK showed shorter overall survival (OS) compared to those without a CK (77 months vs. 115 months, p < 0.0001). Chromosomes most frequently included in a CK were 13, 11, 17, 8, 2, and 6. The most common aberrations in a CK were translocations, numerical changes and dicentric chromosomes (with no effect on OS). Patients with aberrations ofTP53 and ATM were shown to have adverse prognosis comparable to patients with a CK without these abnormalities. A stronger impact of a CK on OS of female and older CLL patients was observed. CONCLUSIONS: The determining of the presence of a CK is essential in modern clinical CLL practice. According to recent studies, the presence of a CK affects clinical and treatment decision-making.
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