The selection of pharmacotherapy for patients with allergic rhinitis aims to control the disease and depends on many factors. Grading of Recommendations Assessment, Development and Evaluation (GRADE) guidelines have considerably improved the treatment of allergic rhinitis. However, there is an increasing trend toward use of real-world evidence to inform clinical practice, especially because randomized controlled trials are often limited with regard to the applicability of results. The Contre les Maladies Chroniques pour un Vieillissement Actif (MACVIA) algorithm has proposed an allergic rhinitis treatment by a consensus group. This simple algorithm can be used to step up or step down allergic rhinitis treatment. Next-generation guidelines for the pharmacologic treatment of allergic rhinitis were developed by using existing GRADE-based guidelines for the disease, real-world evidence provided by mobile technology, and additive studies (allergen chamber studies) to refine the MACVIA algorithm.

Allergist La Rochelle France

Allergist Montevideo Uruguay

Allergist Reims France

Allergy and Asthma Center Westend Outpatient and Clinical Research Center Berlin Germany

Allergy and Clinical Immunology Department Centro Medico Docente La Trinidad Caracas Venezuela

Allergy and Respiratory Diseases Ospedale Policlino San Martino University of Genoa Genoa Italy

Allergy and Respiratory Research Group University of Edinburgh Edinburgh United Kingdom

Allergy Department Pasteur Institute Paris France

Allergy Section Department of Internal Medicine Hospital Vall d'Hebron and ARADyAL research network Barcelona Spain

Association Asthme et Allergie Paris France

Asthma UK London United Kingdom

Center for Rhinology and Allergology Wiesbaden Germany

Center of Allergy Immunology and Respiratory Diseases Santa Fe and the Center for Allergy and Immunology Santa Fe Argentina

Center of Excellence in Asthma and Allergy Médica Sur Clinical Foundation and Hospital Mexico City Mexico

Charité Universitätsmedizin Berlin corporate member of Freie Universität Berlin Humboldt Uniersität zu Berlin and Berlin Institute of Health Comprehensive Allergy Centre Department of Dermatology and Allergy member of GA LEN Berlin Germany

CHU Dijon Dijon France

CINTESIS Center for Research in Health Technology and Information Systems Faculdade de Medicina da Universidade do Porto and Medida Porto Portugal

CIRFF Center of Pharmacoeconomics University of Naples Federico 2 Naples Italy

Clinical Research Center for Allergy and Rheumatology Sagamihara National Hospital Sagamihara Japan

David Hide Centre St Mary's Hospital Isle of Wight and University of Southampton Southampton United Kingdom

Department of Allergy and Clinical Immunology Ajou University School of Medicine Suwon South Korea

Department of Allergy and Immunology Hospital Quirónsalud Bizkaia Erandio Spain

Department of Allergy Immunology and Respiratory Medicine Alfred Hospital and Central Clinical School Monash University Melbourne and the Department of Immunology Monash University Melbourne Australia

Department of Clinical Immunology Wrocław Medical University Wroclaw Poland

Department of Health Research Methods Evidence and Impact Division of Immunology and Allergy McMaster University Hamilton Ontario Canada

Department of Immunology and Allergology Faculty of Medicine in Pilsen Charles University Prague Pilsen Czech Republic

Department of Immunology and Allergy Healthy Ageing Research Center Medical University of Lodz Lodz Poland

Department of Internal Medicine section of Allergology Erasmus MC Rotterdam The Netherlands

Department of Lung Diseases and Clinical Immunology University of Turku and Terveystalo Allergy Clinic Turku Finland

Department of Medicine Clinical Immunology and Allergy McMaster University Hamilton Ontario Canada

Department of Otorhinolaryngology Amsterdam University Medical Centres AMC Amsterdam The Netherlands

Department of Otorhinolaryngology Chiba University Hospital Chiba Japan

Department of Otorhinolaryngology Head and Neck Surgery Section of Rhinology and Allergy University Hospital Marburg Philipps Universität Marburg Marburg Germany

Department of Otorhinolaryngology University Hospitals Leuven and Academic Medical Center University of Amsterdam The Netherlands and Euforea Brussels Belgium

Department of Paediatric Pneumology Immunology and Intensive Care Charité Universitätsmedizin Berlin Germany

Department of Pharmacy of University of Naples Federico 2 Naples Italy

Department of Prevention of Envinronmental Hazards and Allergology Medical University of Warsaw Warsaw Poland

Department of Pulmonary Diseases Celal Bayar University Faculty of Medicine Manisa Turkey

Department of Pulmonary Diseases Istanbul University Cerrahpasa Cerrahpasa Faculty of Medicine Istanbul Turkey

Department of Respiratory Medicine Ghent University Hospital Ghent Belgium

Department of Social Medicine Faculty of Medicine University of Crete and International Primary Care Respiratory Group Crete Greece

Departments of Internal Medicine and Pediatrics University of Tennessee College of Medicine Germantown Tenn

Division of Allergy Immunology and Transplantation National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda Md

Division of Internal Medicine Asthma and Allergy Barlicki University Hospital Medical University of Lodz Lodz Poland

Division of Respiratory and Allergic Diseases Hospital A Cardarelli University of Naples Federico 2 Naples Italy

Euforea Brussels Belgium

Faculty of Health Sciences and CICS UBI Health Sciences Research Centre University of Beira Interior Covilhã Portugal

Faculty of Medicine Transylvania University Brasov Romania

Food Allergy Referral Centre Veneto Region Department of Women and Child Health Padua General University Hospital Padua Italy

Hans Christian Andersen Children's Hospital Odense University Hospital Odense Denmark

Hospital de Clinicas University of Parana Parana Brazil

Hospital de Dona Estefânia Centro Hospitalar de Lisboa Central EPE Lisbon and Nova Medical School CEDOC Integrated Pathophysiological Mechanisms Research Group Lisbon Portugal

Immunomodulation and Tolerance Group and Allergy and Clinical Immunology Imperial College London London United Kingdom

Imperial College London National Heart and Lung Institute Royal Brompton Hospital NHS London United Kingdom

Imunoalergologia Centro Hospitalar Universitário de Coimbra and Faculty of Medicine University of Coimbra Coimbra Portugal

Institute for Immunological Research University of Cartagena Campus de Zaragocilla Edificio Biblioteca Primer Piso and the Foundation for the Development of Medical and Biological Sciences Cartagena Colombia

Institute of Biomedical Sciences Department of Pathology Faculty of Medicine Vilnius University and Institute of Clinical medicine Clinic of Chest diseases and Allergology Faculty of Medicine Vilnius University Vilnius Lithuania

Institute of Biomedicine and Molecular Immunology Palermo Italy

Institute of Medical Statistics and Computational Biology Medical Faculty University of Cologne and Clinical Research International Hamburg Germany

iQ4U Consultants London United Kingdom

KYomed INNOV Montpellier France

Laval University Quebec City Quebec Canada

MACVIA France Fondation Partenariale FMC VIA LR Montpellier France

MACVIA France Fondation Partenariale FMC VIA LR Montpellier France; VIMA INSERM U 1168 VIMA Ageing and chronic diseases Epidemiological and public health approaches Villejuif France Université Versailles St Quentin en Yvelines UMR S 1168 Montigny le Bretonneux Euforea Brussels Belgium and Charité Universitätsmedizin Berlin Humboldt Universität zu Berlin and Berlin Institute of Health Comprehensive Allergy Center Department of Dermatology and Allergy Berlin Germany

Medical Consulting Czarlewski Levallois France

National Hospital Organization Tokyo National Hospital Tokyo Japan

National Institute for Health and Welfare Helsinki Finland

National Research Center Institute of Immunology Federal Medicobiological Agency Laboratory of Molecular immunology Moscow Russia

Nova Southeastern University Fort Lauderdale Fla

Observational and Pragmatic Research Institute Singapore

Oslo University Hospital Department of Paediatrics Oslo and University of Oslo Faculty of Medicine Institute of Clinical Medicine Oslo Norway

Pediatric Allergy and Asthma Unit Hacettepe University School of Medicine Ankara Turkey

Personalized Medicine Clinic Asthma and Allergy Humanitas University Humanitas Research Hospital Rozzano Milan Italy

Pneumologie et Soins Intensifs Respiratoires Hôpitaux Universitaires Paris and Hôpital Cochin Paris France

ProAR Nucleo de Excelencia em Asma Federal University of Bahia and the WHO GARD Planning Group Bahia Brazil

Quebec Heart and Lung Institute Laval University Quebec City Quebec Canada

Rhinology Unit and Smell Clinic ENT Department Hospital Clínic and Clinical and Experimental Respiratory Immunoallergy IDIBAPS CIBERES University of Barcelona Barcelona Spain

Royal National TNE Hospital University College London London United Kingdom

Sachs' Children and Youth Hospital Södersjukhuset Stockholm and Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden

Scientific Centre of Children's Health under the MoH Moscow and Russian National Research Medical University named Pirogov Moscow Russia

Section of Allergy and Immunology Saint Louis University School of Medicine St Louis Mo

Servicio de Alergia e Immunologia Clinica Santa Isabel Buenos Aires Argentina

Skin and Allergy Hospital Helsinki University Hospital and University of Helsinki Helsinki Finland

SOS Allergology and Clinical Immunology USL Toscana Centro Prato Italy

the Division of Allergy Immunology University of South Florida Tampa Fla

UCIBIO REQUIMTE Faculty of Pharmacy and Competence Center on Active and Healthy Ageing of University of Porto University of Porto Porto Portugal

Ukrainina Medical Stomatological Academy Poltava Ukraine

Unité de pneumo allergologie de l'enfant pôle pédiatrique Pr Labbé CHU de Clermont Ferrand Estaing Clermont Ferrand France

Unité Médico Economie Département de l'Information Médicale University Hospital Montpellier France

University of Bari Medical School Unit of Geriatric Immunoallergology Bari Italy

University of Medicine and Pharmacy Ho Chi Minh City Vietnam

Upper Airways Research Laboratory ENT Department Ghent University Hospital Ghent Belgium

UPRES EA220 Pôle des Maladies des Voies Respiratoires Hôpital Foch Université Paris Saclay Suresnes France; Allergy and Clinical Immunology Section National Heart and Lung Institute Imperial College London London United Kingdom

Usher Institute of Population Health Sciences and Informatics University of Edinburgh Edinburgh United Kingdom

Vilnius University Institute of Clinical Medicine Clinic of Children's Diseases and Institute of Health Sciences Department of Public Health Vilnius Mexico and the European Academy of Paediatrics Brussels Belgium

Woolcock Institute of Medical Research University of Sydney and Woolcock Emphysema Centre and Sydney Local Health District Glebe Australia

Erratum In

J Allergy Clin Immunol. 2022 Jun;149(6):2180. doi: 10.1016/j.jaci.2022.04.016. PubMed

References provided by Crossref.org

Digitally-enabled, patient-centred care in rhinitis and asthma multimorbidity: The ARIA-MASK-air® approach

Allergen immunotherapy in MASK-air users in real-life: Results of a Bayesian mixed-effects model

Next-generation ARIA care pathways for rhinitis and asthma: a model for multimorbid chronic diseases