DNA repair capacity and response to treatment of colon cancer
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
31691643
DOI
10.2217/pgs-2019-0070
Knihovny.cz E-resources
- Keywords
- DNA repair, DNA repair capacity, colon cancer, prediction of therapy response, prognosis,
- MeSH
- Cell Death drug effects MeSH
- Epigenesis, Genetic genetics MeSH
- Humans MeSH
- Mutation MeSH
- Colonic Neoplasms drug therapy genetics pathology MeSH
- Genomic Instability drug effects genetics MeSH
- DNA Repair drug effects MeSH
- DNA Damage drug effects MeSH
- Prognosis MeSH
- Gene Expression Regulation, Neoplastic drug effects MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
DNA repair, a complex biological process, ensures genomic integrity. Alterations in DNA repair, occurring in many cancers, contribute to the accumulation of mutations in the genome, resulting in genomic instability and cancer progression. DNA repair also plays a substantial role in response to chemotherapeutics: rapidly dividing colon cancer cells, vulnerable to DNA-damaging agents and overcoming DNA repair, undergo cell death. DNA repair capacity represents a complex biomarker, integrating gene variants, gene expressions, the stability of gene products, the effect of inhibitors/stimulators, lifestyle and environmental factors. Here, we discuss DNA repair capacity in sporadic colon cancer, a frequent malignancy worldwide, in relation to tumor heterogeneity, prognosis and prediction, measurements in surrogate and target tissues and suggest important tasks to be addressed.
References provided by Crossref.org
DNA Repair and Ovarian Carcinogenesis: Impact on Risk, Prognosis and Therapy Outcome
