Impact of APOE and BDNF Val66Met Gene Polymorphisms on Cognitive Functions in Patients with Amnestic Mild Cognitive Impairment
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
31771052
DOI
10.3233/jad-190464
PII: JAD190464
Knihovny.cz E-resources
- Keywords
- Alzheimer’s disease, Apolipoprotein E, amnestic mild cognitive impairment, brain-derived neurotrophic factor, cognition, gene polymorphism,
- MeSH
- Amnesia psychology MeSH
- Apolipoprotein E4 genetics MeSH
- Atrophy MeSH
- Heterozygote MeSH
- Hippocampus diagnostic imaging MeSH
- Cognition * MeSH
- Cognitive Dysfunction genetics psychology MeSH
- Middle Aged MeSH
- Humans MeSH
- Magnetic Resonance Imaging MeSH
- Brain diagnostic imaging MeSH
- Brain-Derived Neurotrophic Factor genetics MeSH
- Neuropsychological Tests MeSH
- Memory MeSH
- Polymorphism, Genetic genetics MeSH
- Mental Recall MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Apolipoprotein E4 MeSH
- BDNF protein, human MeSH Browser
- Brain-Derived Neurotrophic Factor MeSH
Apolipoprotein (APOE) ɛ4 is a well-known risk factor for late-onset Alzheimer's disease (AD), but other AD-related gene polymorphisms might also be important, such as the polymorphism within the brain-derived neurotrophic factor (BDNF) gene. Carriage of BDNF Val66Met has been associated with faster cognitive decline and greater hippocampal atrophy in cognitively normal elderly. Thus, we examined the effects of the concurrent presence of APOE and BDNF polymorphisms on cognitive functions and brain morphometry in amnestic mild cognitive impairment (aMCI) patients. 107 aMCI patients (mean age = 72.2) were recruited from the Czech Brain Aging Study and, based on APOE and BDNF genes polymorphisms, were divided into four groups: ɛ4-BDNFVal/Val (n = 37), ɛ4-BDNFMet (n = 19), ɛ4+BDNFVal/Val (n = 35), and ɛ4+BDNFMet (n = 16). All patients underwent clinical examination, magnetic resonance imaging, and complex neuropsychological battery. The combination of APOEɛ4+ and BDNF Met was associated with significantly worse memory performance in immediate and delayed recall compared to other polymorphism groups. We did not observe increased atrophy in areas related to memory function in the ɛ4+BDNFMet group. Our findings suggest that carriage of ɛ4+BDNFMet is associated with more pronounced memory dysfunction, a typical feature of early AD, but not with structural brain changes in aMCI patients. These findings suggest that in APOEɛ4/BDNF Met carriers, synaptic dysfunction affecting memory may precede pronounced structural changes.
Department of Clinical Biochemistry Hematology and Immunology Homolka Hospital Prague Czech Republic
International Clinical Research Center St Anne's University Hospital Brno Brno Czech Republic
School of Aging Studies University of South Florida Tampa FL USA
References provided by Crossref.org
Emotional prosody recognition is impaired in Alzheimer's disease
The Combined Effect of APOE and BDNF Val66Met Polymorphisms on Spatial Navigation in Older Adults
