Serotonin transporter gene (SLC6A4) variability in patients with recurrent aphthous stomatitis
Language English Country Great Britain, England Media print-electronic
Document type Journal Article
PubMed
31846848
DOI
10.1016/j.archoralbio.2019.104628
PII: S0003-9969(19)30997-5
Knihovny.cz E-resources
- Keywords
- Polymorphism, Recurrent aphthous stomatitis, SLC6A4, Serotonin transporter gene,
- MeSH
- Stomatitis, Aphthous * genetics MeSH
- Gene Frequency MeSH
- Genotype MeSH
- Polymorphism, Single Nucleotide MeSH
- Humans MeSH
- Serotonin Plasma Membrane Transport Proteins * genetics MeSH
- Recurrence MeSH
- Case-Control Studies MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Geographicals
- Czech Republic MeSH
- Names of Substances
- Serotonin Plasma Membrane Transport Proteins * MeSH
- SLC6A4 protein, human MeSH Browser
OBJECTIVE: The aim of this study was to investigate five polymorphisms in the SLC6A4 gene in patients with recurrent aphthous stomatitis (RAS) and healthy controls. DESIGN: Totally, 239 subjects were enrolled in this case-control study: 86 patients with RAS and 153 healthy individuals were genotyped for serotonin transporter length polymorphic region (5-HTTLPR) polymorphism, variable number tandem repeat (STin2) and single nucleotide polymorphisms (rs25531, rs3813034, rs1042173) in the SLC6A4 gene by polymerase chain reaction with/without restriction analysis. RESULTS: No significant differences in the allele or genotype frequencies in all studied polymorphisms between RAS patients and healthy controls (P > 0.05) were detected. However, the haplotype analysis detected a higher frequency of LA12 (HTTLPR, rs25531, STin2) haplotype in RAS patients in comparison with healthy controls (P < 0.05, OR = 1.63, 95 % CI = 1.07-2.49). CONCLUSIONS: Our study indicates a possible relationship between SLC6A4 and susceptibility to RAS in the Czech population.
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