Acute low-dose bisphenol S exposure affects mouse oocyte quality
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
31881267
DOI
10.1016/j.reprotox.2019.12.005
PII: S0890-6238(19)30692-6
Knihovny.cz E-zdroje
- Klíčová slova
- DNA methylation, Endocrine disruptors, Epigenetics, Histone modifications, Meiotic spindle, Oocyte development,
- MeSH
- embryonální vývoj účinky léků MeSH
- fenoly toxicita MeSH
- metylace DNA účinky léků MeSH
- myši inbrední ICR MeSH
- oocyty účinky léků metabolismus MeSH
- poškození DNA MeSH
- stanovení celkové genové exprese MeSH
- sulfony toxicita MeSH
- těhotenství MeSH
- vývojová regulace genové exprese účinky léků MeSH
- zvířata MeSH
- Check Tag
- těhotenství MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- bisphenol S MeSH Prohlížeč
- fenoly MeSH
- sulfony MeSH
Bisphenol S (BPS) is widely used to replace the known endocrine disruptor BPA in various products. We evaluated the effect of acute in vivo BPS exposure on oocyte quality, simulating the oral route of exposure via oral gavage. Eight-week-old ICR female mice (N = 15 per experimental group) were exposed to vehicle or BPS1-BPS4 (0.001, 0.1, 10, and 100 ng BPS x g bw-1 day-1, respectively) for seven days. Oocytes were isolated and matured in vitro. We observed that BPS exposure increased aberrant spindle formation in mature oocytes and induced DNA damage. Moreover, BPS3 significantly increased the chromatin repressive marks 5-methyl cytosine (5meC) and H3K27me2 in immature oocytes. In the BPS2 group, the increase in 5meC occurred during oocyte maturation. Transcriptome analysis revealed differential expression of early embryonic development transcripts in BPS2-exposed oocytes. These findings indicate that the biological effect of BPS is non-monotonic, affecting oocyte quality even at concentrations that are orders of magnitude below those measured in humans.
Biomedical Center Faculty of Medicine in Pilsen Charles University Pilsen Czech Republic
Faculty of Medicine Charles University Prague Czech Republic
Institute of Animal Science Prague 10 Uhrineves Czech Republic
Citace poskytuje Crossref.org
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