Acute low-dose bisphenol S exposure affects mouse oocyte quality
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
31881267
DOI
10.1016/j.reprotox.2019.12.005
PII: S0890-6238(19)30692-6
Knihovny.cz E-resources
- Keywords
- DNA methylation, Endocrine disruptors, Epigenetics, Histone modifications, Meiotic spindle, Oocyte development,
- MeSH
- Embryonic Development drug effects MeSH
- Phenols toxicity MeSH
- DNA Methylation drug effects MeSH
- Mice, Inbred ICR MeSH
- Oocytes drug effects metabolism MeSH
- DNA Damage MeSH
- Gene Expression Profiling MeSH
- Sulfones toxicity MeSH
- Pregnancy MeSH
- Gene Expression Regulation, Developmental drug effects MeSH
- Animals MeSH
- Check Tag
- Pregnancy MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- bisphenol S MeSH Browser
- Phenols MeSH
- Sulfones MeSH
Bisphenol S (BPS) is widely used to replace the known endocrine disruptor BPA in various products. We evaluated the effect of acute in vivo BPS exposure on oocyte quality, simulating the oral route of exposure via oral gavage. Eight-week-old ICR female mice (N = 15 per experimental group) were exposed to vehicle or BPS1-BPS4 (0.001, 0.1, 10, and 100 ng BPS x g bw-1 day-1, respectively) for seven days. Oocytes were isolated and matured in vitro. We observed that BPS exposure increased aberrant spindle formation in mature oocytes and induced DNA damage. Moreover, BPS3 significantly increased the chromatin repressive marks 5-methyl cytosine (5meC) and H3K27me2 in immature oocytes. In the BPS2 group, the increase in 5meC occurred during oocyte maturation. Transcriptome analysis revealed differential expression of early embryonic development transcripts in BPS2-exposed oocytes. These findings indicate that the biological effect of BPS is non-monotonic, affecting oocyte quality even at concentrations that are orders of magnitude below those measured in humans.
Biomedical Center Faculty of Medicine in Pilsen Charles University Pilsen Czech Republic
Faculty of Medicine Charles University Prague Czech Republic
Institute of Animal Science Prague 10 Uhrineves Czech Republic
References provided by Crossref.org
Nursing Exposure to Bisphenols as a Cause of Male Idiopathic Infertility
