(Meth)acrylate copolymers of Eudragit® type in oral tablet technology
Language English Country Czech Republic Media print
Document type Journal Article, Review
PubMed
31896262
PII: 119280
Knihovny.cz E-resources
- Keywords
- Eudragit®, acidoresistant tablets, burst effect, colon drug delivery, film-coating tablets, floating tablets, matrix tablets, prolonged drug release,
- MeSH
- Chemistry, Pharmaceutical * MeSH
- Polymethacrylic Acids chemistry MeSH
- Delayed-Action Preparations MeSH
- Solubility MeSH
- Tablets * MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Names of Substances
- Polymethacrylic Acids MeSH
- Delayed-Action Preparations MeSH
- methylmethacrylate-methacrylic acid copolymer MeSH Browser
- Tablets * MeSH
This review focuses on the characterization of (meth)acrylate copolymers - Eudragit®, describing their thermal treatment behaviour, possible interactions between cationic and anionic polymers, incompatibilities related to Eudragits® and their use in the pharmaceutical technology of oral tablets. In summary, Eudragit® copolymers are divided into soluble ones, insoluble ones and a combination of these two types. The combination of soluble and insoluble poly(meth)acrylate gave a new type of polymer, Eudragit® FL. In oral tablet technology, Eudragits® are widely used in matrix tablets, either alone or in combination, where they mainly provide sustained drug release. To a lesser extent, Eudragits® are used in gastroretentive systems. Moreover, Eudragits® are also of great importance in coated tablets technology, where these enteric polymers provide specific drug targeting to certain parts of the digestive tract, mainly to the small intestine or colon. Important systems such as CODESTM and MMX® technology are mentioned. Last but not least an overview table of currently available oral medicinal products on the Czech market, where at least one of the Eudragits® was used as a film-forming agent, is included.