Effect of Calanus Oil Supplementation and 16 Week Exercise Program on Selected Fitness Parameters in Older Women
Language English Country Switzerland Media electronic
Document type Journal Article
Grant support
16-29182A
Agentura Pro Zdravotnický Výzkum České Republiky
Q 41
Univerzita Karlova v Praze
PubMed
32074977
PubMed Central
PMC7071248
DOI
10.3390/nu12020481
PII: nu12020481
Knihovny.cz E-resources
- Keywords
- calanus oil, circuit training, nordic walking, older age,
- MeSH
- Time Factors MeSH
- Copepoda chemistry MeSH
- Exercise physiology MeSH
- Dietary Fats, Unsaturated administration & dosage isolation & purification MeSH
- Physical Conditioning, Human methods physiology MeSH
- Humans MeSH
- Fatty Acids, Omega-3 MeSH
- Dietary Supplements * MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Hand Strength MeSH
- Muscle Strength MeSH
- Physical Fitness * MeSH
- Age Factors MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Dietary Fats, Unsaturated MeSH
- Fatty Acids, Omega-3 MeSH
We investigated changes in functional fitness after an exercise program in combination with Calanus oil supplementation, a novel source of bioactive lipids rich in wax esters with omega-3 polyunsaturated fatty acid (n-3 PUFA). Fifty-five healthy sedentary women aged 65-80 (mean age 70.9 ± 3.9 years, BMI 27.24 ± 3.9 kg m-2, VO2peak 19.46 ± 3.7 ml kg-1 min-1) were enrolled in the study. The participants were divided into two groups: exercise training plus Calanus Oil supplementation (n = 28) or exercise plus placebo (sunflower oil) supplementation (n = 27). The exercise intervention program was completed by 53 participants and contained functional circuit training (twice a week, 45 min plus 15 min of stretching and balance training) and Nordic walking (once a week, 60 min) for 16 weeks. Senior fitness test, exercise stress test on bicycle ergometer, hand-grip, and body composition were evaluated before and after the program. Our results show that functional fitness and body composition improved following the interventional exercise program, but for most of the parameters there was no synergic effect of supplementing n-3 PUFA-rich Calanus oil. In comparison to the placebo group, the group with Calanus supplementation experienced significantly higher improvement of functional strength of lower body which was evaluated by the chair stand test. Supplementation with Calanus may have a synergic effect with exercise on functional strength of the lower body in the elderly.
3rd Faculty of Medicine Charles University 110 00 Prague Czech Republic
Faculty of Physical Education and Sport Charles University 162 52 Prague Czech Republic
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Wilkinson D.J., Piasecki M., Atherton P.J. The age-related loss of skeletal muscle mass and function: Measurement and physiology of muscle fibre atrophy and muscle fibre loss in humans. Ageing Res. Rev. 2018;47:123–132. doi: 10.1016/j.arr.2018.07.005. PubMed DOI PMC
Grimby G., Saltin B. The aging muscle. Clin. Physiol. 1983;3:209–218. doi: 10.1111/j.1475-097X.1983.tb00704.x. PubMed DOI
Lexell J. Human aging, muscle mass, and fiber type composition. J. Gerontol. Ser. A Biol. Sci. Med Sci. 1995;50:11–16. PubMed
Hughes V.A., Frontera W.R., Wood M., Evans W.J., Dallal G.E., Roubenoff R., Fiatarone Singh M.A. Longitudinal muscle strength changes in older adults: Influence of muscle mass, physical activity, and health. J. Gerontol. Ser. A Biol. Sci. Med Sci. 2001;56:B209–B217. doi: 10.1093/gerona/56.5.B209. PubMed DOI
Leenders M., Verdijk L.B., van der Hoeven L., van Kranenburg J., Nilwik R., van Loon L.J. Elderly men and women benefit equally from prolonged resistance-type exercise training. J. Gerontol. Ser. A Biol. Sci. Med Sci. 2013;68:769–779. doi: 10.1093/gerona/gls241. PubMed DOI
Irving B.A., Lanza I.R., Henderson G.C., Rao R.R., Spiegelman B.M., Nair K.S. Combined Training Enhances Skeletal Muscle Mitochondrial Oxidative Capacity Independent of Age. J. Clin. Endocrinol. Metab. 2015;100:1654–1663. doi: 10.1210/jc.2014-3081. PubMed DOI PMC
Gillespie L.D., Robertson M.C., Gillespie W.J., Sherrington C., Gates S., Clemson L.M., Lamb S.E. Interventions for preventing falls in older people living in the community. Cochrane Database Syst. Rev. 2012;9:Cd007146. doi: 10.1002/14651858.CD007146.pub3. PubMed DOI PMC
Paddon-Jones D., Sheffield-Moore M., Zhang X.J., Volpi E., Wolf S.E., Aarsland A., Wolfe R.R. Amino acid ingestion improves muscle protein synthesis in the young and elderly. Am. J. Physiol. Endocrinol. Metab. 2004;286:E321–E328. doi: 10.1152/ajpendo.00368.2003. PubMed DOI
Symons T.B., Schutzler S.E., Cocke T.L., Chinkes D.L., Wolfe R.R., Paddon-Jones D. Aging does not impair the anabolic response to a protein-rich meal. Am. J. Clin. Nutr. 2007;86:451–456. doi: 10.1093/ajcn/86.2.451. PubMed DOI
Nilsson A., Rojas D.M., Kadi F. Impact of Meeting Different Guidelines for Protein Intake on Muscle Mass and Physical Function in Physically Active Older Women. Nutrients. 2018;10:1156. doi: 10.3390/nu10091156. PubMed DOI PMC
Smith G.I., Julliand S., Reeds D.N., Sinacore D.R., Klein S., Mittendorfer B. Fish oil-derived n-3 PUFA therapy increases muscle mass and function in healthy older adults. Am. J. Clin. Nutr. 2015;102:115–122. doi: 10.3945/ajcn.114.105833. PubMed DOI PMC
Lalia A.Z., Dasari S., Robinson M.M., Abid H., Morse D.M., Klaus K.A., Lanza I.R. Influence of omega-3 fatty acids on skeletal muscle protein metabolism and mitochondrial bioenergetics in older adults. Aging. 2017;9:1096–1115. doi: 10.18632/aging.101210. PubMed DOI PMC
Cook C.M., Larsen T.S., Derrig L.D., Kelly K.M., Tande K.S. Wax Ester Rich Oil from the Marine Crustacean, Calanus finmarchicus, is a Bioavailable Source of EPA and DHA for Human Consumption. Lipids. 2016;51:1137–1144. doi: 10.1007/s11745-016-4189-y. PubMed DOI
Höper A.C., Salma W., Khalid A.M., Hafstad A.D., Sollie S.J., Raa J., Larsen T.S., Aasum E. Oil from the marine zooplankton Calanus finmarchicus improves the cardiometabolic phenotype of diet-induced obese mice. Br. J. Nutr. 2013;110:2186–2193. doi: 10.1017/S0007114513001839. PubMed DOI
Höper A.C., Salma W., Sollie S.J., Hafstad A.D., Lund J., Khalid A.M., Raa J., Aasum E., Larsen T.S. Wax Esters from the Marine Copepod Calanus finmarchicus Reduce Diet-Induced Obesity and Obesity-Related Metabolic Disorders in Mice. J. Nutr. 2014;144:164–169. doi: 10.3945/jn.113.182501. PubMed DOI
Da Boit M., Sibson R., Sivasubramaniam S., Meakin J.R., Greig C.A., Aspden R.M., Gray S.R. Sex differences in the effect of fish-oil supplementation on the adaptive response to resistance exercise training in older people: A randomized controlled trial. Am. J. Clin. Nutr. 2017;105:151–158. doi: 10.3945/ajcn.116.140780. PubMed DOI PMC
Dupont J., Dedeyne L., Dalle S., Koppo K., Gielen G. The role of omega-3 in the prevention and treatment of sarcopenia. Aging Clin. Exp. Res. 2019;31:825–836. doi: 10.1007/s40520-019-01146-1. PubMed DOI PMC
De Lourdes NahhasRodacki C., Rodacki A.L., Coelho I., Pequito D., Krause M., Bonatto S., Fernandes L.C. Influence of fish oil supplementation and strength training on some functional aspects of immune cells in healthy elderly women. Br. J. Nutr. 2015;114:43–52. doi: 10.1017/S0007114515001555. PubMed DOI
Edholm P., Strandberg E., Kadi F. Lower limb explosive strength capacity in elderly women: Effects of resistance training and healthy diet. J. Appl. Physiol. 2017;123:190–196. doi: 10.1152/japplphysiol.00924.2016. PubMed DOI
Rikli R.E., Jones C.J. Senior Fitness Test Manual. Human Kinetics; Champaign, IL, USA: 2001.
Machačova K., Bunc V., Vaňkova H., Holmerova I., Veleta P. Zkušenosti s hodnocenim tělesne zdatnosti seniorů metodou “Senior Fitness Test”. Ceska Geriatricka Revue. 2007;5:248–253.
Borg G. Perceived Exertion and Pain Scales. Human Kinetics; Champaign, IL, USA: 1998.
Breen L., Phillips S.M. Skeletal muscle protein metabolism in the elderly: Interventions to counteract the ‘anabolic resistance’ of aging. Nutr. Metab. 2011;8:68. doi: 10.1186/1743-7075-8-68. PubMed DOI PMC
Lilja M., Mandić M., Apró W., Melin M., Olsson K., Rosenborg S., Lundberg T.R. High doses of anti-inflammatory drugs compromise muscle strength and hypertrophic adaptations to resistance training in young adults. Acta Physiol. 2018;222:e12948. doi: 10.1111/apha.12948. PubMed DOI
EFSA Panel on Dietetic Products, Nutrition & Allergies Scientific Opinion on the Tolerable Upper Intake Level of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and docosapentaenoic acid (DPA) EFSA J. 2012;10:2815. doi: 10.2903/j.efsa.2012.2815. DOI
Pedersen A.M., Salma W., Hoper A.C., Larsen T.S., Olsen R.L. Lipid profile of mice fed a high-fat diet supplemented with a wax ester-rich marine oil. Eur. J. Lipid Sci. Technol. 2014;116:1718–1726. doi: 10.1002/ejlt.201400052. DOI
Gasmi A., Mujawdiya P.K., Shanaida M., Ongenae A., Lysiuk R., Dosa M.D., Bjorklund G. Calanus Oil in the treatment of obesity-related low-grade inflammation, insulin resistance, and atherosclerosis. Appl. Microbiol. Biotechnol. 2019 doi: 10.1007/s00253-019-10293-4. PubMed DOI
Rodacki C.L., Rodacki A.L., Pereira G., Naliwaiko K., Coelho I., Pequito D., Fernandes L.C. Fish-oil supplementation enhances the effects of strength training in elderly women. Am. J. Clin. Nutr. 2012;95:428–436. doi: 10.3945/ajcn.111.021915. PubMed DOI
McGlory C., Calder P.C., Nunes E.A. The Influence of Omega-3 Fatty Acids on Skeletal Muscle Protein Turnover in Health, Disuse, and Disease. Front. Nutr. 2019;6:144. doi: 10.3389/fnut.2019.00144. PubMed DOI PMC
Brezinova M., Cajka M., Oseeva M., Stepan M., Dadova K., Rossmeislova L., Matous M., Siklova M., Rossmeisl M., Kuda O. Exercise training induces insulin-sensitizing PAHSAs in adipose tissue of elderly women. Biochim. Biophys. Acta (BBA)-Mol. Cell Biol. Lipids. 2020;1865:158576. doi: 10.1016/j.bbalip.2019.158576. PubMed DOI
Puciato D., Borysiuk Z., Rozpara M. Quality of life and physical activity in an older working-age population. Clin. Interv. Aging. 2017;12:1627–1634. doi: 10.2147/CIA.S144045. PubMed DOI PMC