Pheochromocytoma With Adrenergic Biochemical Phenotype Shows Decreased GLP-1 Secretion and Impaired Glucose Tolerance
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
32222768
DOI
10.1210/clinem/dgaa154
PII: 5813460
Knihovny.cz E-resources
- Keywords
- glucagon, incretins, insulin, meal test, pheochromocytoma, secondary diabetes mellitus,
- MeSH
- Adrenergic Agents adverse effects MeSH
- Biomarkers metabolism MeSH
- Adult MeSH
- Phenotype MeSH
- Pheochromocytoma complications MeSH
- Gastrointestinal Hormones metabolism MeSH
- Glucagon-Like Peptide 1 metabolism MeSH
- Incretins adverse effects MeSH
- Meals MeSH
- Blood Glucose analysis MeSH
- Middle Aged MeSH
- Humans MeSH
- Adrenal Gland Neoplasms complications MeSH
- Follow-Up Studies MeSH
- Pancreatic Hormones metabolism MeSH
- Glucose Intolerance etiology metabolism pathology MeSH
- Prognosis MeSH
- Prospective Studies MeSH
- Aged MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Adrenergic Agents MeSH
- Biomarkers MeSH
- Gastrointestinal Hormones MeSH
- Glucagon-Like Peptide 1 MeSH
- Incretins MeSH
- Blood Glucose MeSH
- Pancreatic Hormones MeSH
CONTEXT: Impaired glucose homeostasis is a common finding in pheochromocytoma (PHEO), especially with adrenergic phenotype. The possible contribution of incretin dysfunction to dysglycemia in PHEO patients has not been studied. OBJECTIVE: To compare changes in pancreatic endocrine function and gut hormones' production during a liquid meal test before and 1 year after adrenalectomy. METHODS: In a prospective study, we included 18 patients with PHEO (13 females) with adrenergic biochemical phenotype. A liquid meal test with predefined isocaloric enteral nutrition was performed to evaluate dynamic changes in pancreatic hormones and incretins. RESULTS: During the meal test, insulin levels were significantly lower before adrenalectomy only in the early phase of insulin secretion, but changes in area under the curve (AUC) did not reach statistical significance (AUC = 0.07). Plasma glucagon (AUC < 0.01) and pancreatic polypeptide levels (AUC < 0.01) were suppressed in comparison with the postoperative state. Impaired response to the meal was found preoperatively for glucagon-like peptide-1 (GLP-1; AUC P < 0.05), but not glucose-dependent insulinotropic polypepide (GIP; AUC P = 0.21). No significant changes in insulin resistance indices were found, except for the homeostatic model assessment-beta index, an indicator of the function of islet β cells, which negatively correlated with plasma metanephrine (R = -0.66, P < 0.01). CONCLUSIONS: Our study shows suppression of pancreatic α and β cell function and impaired GLP-1 secretion during a dynamic meal test in patients with PHEO, which is improved after its surgical treatment. These data demonstrate a novel and potentially significant interconnection between excessive catecholamine production and the secretion of glucoregulatory hormones.
References provided by Crossref.org
