Pheochromocytoma With Adrenergic Biochemical Phenotype Shows Decreased GLP-1 Secretion and Impaired Glucose Tolerance
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
32222768
DOI
10.1210/clinem/dgaa154
PII: 5813460
Knihovny.cz E-zdroje
- Klíčová slova
- glucagon, incretins, insulin, meal test, pheochromocytoma, secondary diabetes mellitus,
- MeSH
- adrenergní látky škodlivé účinky MeSH
- biologické markery metabolismus MeSH
- dospělí MeSH
- fenotyp MeSH
- feochromocytom komplikace MeSH
- gastrointestinální hormony metabolismus MeSH
- glukagonu podobný peptid 1 metabolismus MeSH
- inkretiny škodlivé účinky MeSH
- jídla MeSH
- krevní glukóza analýza MeSH
- lidé středního věku MeSH
- lidé MeSH
- nádory nadledvin komplikace MeSH
- následné studie MeSH
- pankreatické hormony metabolismus MeSH
- porucha glukózové tolerance etiologie metabolismus patologie MeSH
- prognóza MeSH
- prospektivní studie MeSH
- senioři MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- adrenergní látky MeSH
- biologické markery MeSH
- gastrointestinální hormony MeSH
- glukagonu podobný peptid 1 MeSH
- inkretiny MeSH
- krevní glukóza MeSH
- pankreatické hormony MeSH
CONTEXT: Impaired glucose homeostasis is a common finding in pheochromocytoma (PHEO), especially with adrenergic phenotype. The possible contribution of incretin dysfunction to dysglycemia in PHEO patients has not been studied. OBJECTIVE: To compare changes in pancreatic endocrine function and gut hormones' production during a liquid meal test before and 1 year after adrenalectomy. METHODS: In a prospective study, we included 18 patients with PHEO (13 females) with adrenergic biochemical phenotype. A liquid meal test with predefined isocaloric enteral nutrition was performed to evaluate dynamic changes in pancreatic hormones and incretins. RESULTS: During the meal test, insulin levels were significantly lower before adrenalectomy only in the early phase of insulin secretion, but changes in area under the curve (AUC) did not reach statistical significance (AUC = 0.07). Plasma glucagon (AUC < 0.01) and pancreatic polypeptide levels (AUC < 0.01) were suppressed in comparison with the postoperative state. Impaired response to the meal was found preoperatively for glucagon-like peptide-1 (GLP-1; AUC P < 0.05), but not glucose-dependent insulinotropic polypepide (GIP; AUC P = 0.21). No significant changes in insulin resistance indices were found, except for the homeostatic model assessment-beta index, an indicator of the function of islet β cells, which negatively correlated with plasma metanephrine (R = -0.66, P < 0.01). CONCLUSIONS: Our study shows suppression of pancreatic α and β cell function and impaired GLP-1 secretion during a dynamic meal test in patients with PHEO, which is improved after its surgical treatment. These data demonstrate a novel and potentially significant interconnection between excessive catecholamine production and the secretion of glucoregulatory hormones.
Citace poskytuje Crossref.org
