Concentration of NK cells after β-glucan and vitamin D supplementation in patients with diabetic retinopathy

. 2020 Aug ; 65 (4) : 755-761. [epub] 20200404

Jazyk angličtina Země Spojené státy americké Médium print-electronic

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/pmid32248405
Odkazy

PubMed 32248405
DOI 10.1007/s12223-020-00789-2
PII: 10.1007/s12223-020-00789-2
Knihovny.cz E-zdroje

In our study, we focused on possible effects of supplementation with glucan and vitamin D on total numbers of NK cells in patients with diabetic retinopathy. We evaluated possible relations among nutritional state (BMI), leptin levels, and total numbers of NK cells in patients supplemented with (1) glucan and vitamin D, (2) vitamin D and placebo, and (3) vitamin D alone. Our results show that 3 months of supplementation with both glucan and vitamin D resulted in significant improvements of NK cell numbers. In addition, we found statistically significant correlation between NK cell numbers and leptin levels. Based on these results, we propose that the molecule responsible for these changes is glucan, as vitamin D alone or together with placebo caused no effects.

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