BACKGROUND: Chronic rhinosinusitis (CRS) is a chronic inflammatory disease associated with a substantial personal and socioeconomic burden. Monitoring of patient-reported outcomes by mobile technology offers the possibility to better understand real-life burden of CRS. METHODS: This study reports on the cross-sectional evaluation of data of 626 users of mySinusitisCoach (mSC), a mobile application for CRS patients. Patient characteristics of mSC users were analysed as well as the level of disease control based on VAS global rhinosinusitis symptom score and adapted EPOS criteria. RESULTS: The mSC cohort represents a heterogeneous group of CRS patients with a diverse pattern of major symptoms. Approximately half of patients reported nasal polyps. 47.3% of all CRS patients were uncontrolled based on evaluation of VAS global rhinosinusitis symptom score compared to 40.9% based on adapted EPOS criteria. The impact of CRS on sleep quality and daily life activities was significantly higher in uncontrolled versus well-controlled patients. Half of patients had a history of FESS (functional endoscopic sinus surgery) and reported lower symptom severity compared to patients without a history of FESS, except for patients with a history of more than 3 procedures. Patients with a history of FESS reported higher VAS levels for impaired smell. CONCLUSION: Real-life data confirm the high disease burden in uncontrolled CRS patients, clearly impacting quality of life. Sinus surgery improves patient-reported outcomes, but not in patients with a history of more than 3 procedures. Mobile technology opens a new era of real-life monitoring, supporting the evolution of care towards precision medicine.

1st Academic ENT Department Aristotle University of Thessaloniki AHEPA University Hospital Thessaloniki Greece

Département d'Otorhinolaryngologie Cliniques Universitaires Saint Luc Brussels Belgium

Department of Clinical Pharmacy and Pharmacology UMCG and QPS NL Groningen The Netherlands

Department of General ORL Head and Neck Surgery Medical University of Graz Graz Austria

Department of Microbiology Immunology and Transplantation Allergy and Clinical Immunology Research Group KU Leuven Belgium

Department of Oto Rhino Laryngology Head and Neck Surgery Lund University Skane University Hospital Lund Sweden

Department of Otorhinolaryngology Akershus University Hospital Lørenskog Norway

Department of Otorhinolaryngology Amsterdam University Medical Centres Amsterdam The Netherlands

Department of Otorhinolaryngology Head and Neck Surgery General Hospital Sint Blasius Dendermonde Belgium

Department of Otorhinolaryngology Head and Neck Surgery University of Crete School of Medicine Heraklion Greece

Department of Otorhinolaryngology Head and Neck Surgery University of Greifswald Germany

Department of Otorhinolaryngology Head and Neck Surgery UZ Leuven UZ Leuven Belgium

Department of Otorhinolaryngology Karolinska Institute Stockholm Sweden

Department of Otorhinolaryngology Odense University Hospital Odense Denmark

Department of Otorhinolaryngology Universitätsklinikum Düsseldorf Dusseldorf Germany

Department of Respiratory Medicine 1st Faculty of Medicine Charles University and Thomayer Hospital Prague Czech Republic

Department of Respiratory Medicine and Allergology Lund University Lund Sweden

Division of ENT Diseases Department of Clinical Science Intervention and Technology Karolinska Institutet Stockholm Sweden

ENT department AZ Damiaan Oostende Belgium

ENT department AZ Delta Roeselare Belgium

ENT department AZ Groeninge Kortrijk Belgium

ENT Department AZ Sint Jan Bruges Belgium

ENT department CHM Mouscron Mouscron Belgium

ENT department Cumberland Infirmary Carlisle UK

ENT Department Faculty of Medicine Hacettepe University Ankara Turkey

ENT department Freeman Hospital Newcastle upon Tyne UK

ENT Department Guy's and St Thomas' NHS Foundation Trust London UK

ENT department Jessa hospital Hasselt Belgium

ENT department Ludwig Maximilians University Munich Germany

ENT Department Royal National Throat Nose and Ear Hospital London UK

ENT department Sint Andriesziekenhuis Tielt Belgium

ENT department Sint Lucas Gent Belgium

ENT department University Hospital of Antwerp Wilrijk Belgium

ENT Department University of Insubria Ospedale Di Circolo E Fondazione Macchi Varese Italy

ENT department ZOL Genk Genk Belgium

European Federation of Allergy and Airways Diseases Patients' Associations Brussels Belgium

European Forum for Research and Education in Allergy and Airway Diseases Brussels Belgium

Haartman Institute Medicum University of Helsinki Helsinki Finland

Hospital Clínic IDIBAPS Universitat de Barcelona CIBERES Barcelona Spain

Life and Health Sciences Research Institute 3B's PT Government Associate Laboratory University of Minho Braga Portugal

Skin and Allergy Hospital Helsinki University Central Hospital Helsinki Finland

Smell and Taste Clinic ENT department Technische Universität Dresden Dresden Germany

Unité de Rhinologie Olfactologie Service d'Oto Rhino Laryngologie et de Chirurgie cervico faciale Hôpitaux Universitaires de Genève Genève Suisse

Universitätsklinik für Hals Nasen Ohrenheilkunde Innsbruck Austria

University of Valencia Valencia Spain

Upper Airways Research Laboratory Department of Otorhinolaryngology Ghent University Belgium

Usher Institute University of Edinburgh UK

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