BACKGROUND: Optimal management of outpatients with heart failure (HF) requires serially updating the estimates of their risk for adverse clinical outcomes to guide treatment. Patient-reported outcomes (PROs) are becoming increasingly used in clinical care. The purpose of this study was to determine whether the inclusion of PROs can improve the risk prediction for HF hospitalization and death in ambulatory patients with HF. METHODS AND RESULTS: We included consecutive patients with HF with reduced ejection fraction (HFrEF) and HF with preserved EF (HFpEF) seen in a HF clinic between 2015 and 2019 who completed PROs as part of routine care. Cox regression with a least absolute shrinkage and selection operator regularization and gradient boosting machine analyses were used to estimate risk for a combined outcome of HF hospitalization, heart transplant, left ventricular assist device implantation, or death. The performance of the prediction models was evaluated with the time-dependent concordance index (Cτ). Among 1165 patients with HFrEF (mean age 59.1 ± 16.1, 68% male), the median follow-up was 487 days. Among 456 patients with HFpEF (mean age 64.2 ± 16.0 years, 55% male) the median follow-up was 494 days. Gradient boosting regression that included PROs had the best prediction performance - Cτ 0.73 for patients with HFrEF and 0.74 in patients with HFpEF, and showed very good stratification of risk by time to event analysis by quintile of risk. The Kansas City Cardiomyopathy Questionnaire overall summary score, visual analogue scale and Patient Reported Outcomes Measurement Information System dimensions of satisfaction with social roles and physical function had high variable importance measure in the models. CONCLUSIONS: PROs improve risk prediction in both HFrEF and HFpEF, independent of traditional clinical factors. Routine assessment of PROs and leveraging the comprehensive data in the electronic health record in routine clinical care could help more accurately assess risk and support the intensification of treatment in patients with HF.

• MeSH
• hodnocení rizik metody   MeSH
• hodnocení výsledků péče pacientem * MeSH
• hospitalizace statistika a číselné údaje   MeSH
• kvalita života * psychologie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• následné studie MeSH
• retrospektivní studie MeSH
• senioři MeSH
• srdeční selhání * patofyziologie   psychologie   terapie   diagnóza   mortalita   MeSH
• tepový objem fyziologie   MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

Alergická rhinitida je onemocnění s vysokou prevalencí. Maximum výskytu je u dětí a v mladším dospělém věku. Odhadem až 500 milionů lidí celosvětově trpí příznaky a onemocnění má významné socioekonomické dopady. Snižuje kvalitu života pacientů a pracovní výkonnost. U dětí zhoršuje soustředění, studijní výsledky a může mít vliv i na poruchy chování. Jedná se o neinfekční zánětlivé onemocnění nosní sliznice na podkladě IgE zprostředkované imunitní odpovědi, která se rozvíjí po kontaktu s alergenem. Alergická rýma je typickým příkladem imunopatologické reakce I. typu. Je často součástí komorbidních stavů jako asthma bronchiale, alergická konjunktivitida nebo atopická dermatitida. Může se podílet na rozvoji chronické rhinosinusitidy. Pro diagnostiku je zásadní podrobná anamnéza s odhalením spouštěčů a časových sousledností. Diferenciálně diagnosticky je třeba odlišit typické příznaky (kýchání, svědění, vodnatá sekrece z nosu, nosní obturace) od jiných projevů. Přítomnost alergické senzibilizace lze většinou prokázat pomocí kožních prick testů. Nové metody molekulární alergologie pomohou zpřesnit alergenovou diagnostiku. Komponentová diagnostika pomocí rekombinantních alergenů může odhalit zkřížené reakce. Nosní provokační testy spolu s rhinomanometrií nebo hodnocením vizuální analogové škály mohou být efektivní u lokální alergické rhinitidy, kde jsou kožní testy i laboratorní hodnoty negativní. Terapeutické postupy spočívají v eliminaci alergenu a ve vícestupňové individualizované medikamentózní léčbě.

Allergic rhinitis is a disease with a high prevalence. The maximum incidence is in children and young adults. It is estimated that up to 500 million people worldwide suffer from symptoms and the disease has significant socioeconomic impacts. It reduces the quality of life of patients, work performance. In children, it impairs concentration, academic performance and can also affect behavioral disorders. It is a non-infectious inflammatory disease of the nasal mucosa based on an IgE-mediated immune response that develops after contact with an allergen. AR is a typical example of a type I immunopathological reaction. It is often part of comorbid conditions such as bronchial asthma, allergic conjunctivitis or atopic dermatitis. It can contribute to the development of chronic rhinosinusitis. A detailed history with the detection of triggers and time sequences is essential for diagnosis. Differential diagnosis requires distinguishing typical symptoms (sneezing, itching, watery nasal discharge, nasal obstruction). Specific allergen sensitisation can usually be determined using skin prick tests. New methods of molecular allergology can improve allergen diagnostics. Component diagnostics using recombinant allergens can reveal crossreactions. Nasal provocation tests together with rhinomanometry or visual analogue scale assessment can be effective in local allergic rhinitis, where skin tests and laboratory values are negative. Therapeutic procedures consist of allergen elimination and multi-stage individualized pharmacological treatment.

BACKGROUND: Schizophrenia is a serious mental illness, the pharmacological treatment of which comprises primarily the use of antipsychotics. However, non-adherence to their use and its reliable determination present a serious clinical and economic problem. This study aimed to determine therapeutic adherence in outpatients with schizophrenia spectrum disorders by combining short-term electronic monitoring of dispenser opening with the measurement of antipsychotic blood concentrations. METHODS: A total of 55 patients underwent a week-long electronic monitoring of dispenser opening and measurement of blood concentrations before and after monitoring. Patients who correctly opened the dispenser at least in 80% of scheduled time points during the weekly interval and, at the same time, did not show a change in blood concentration of the antipsychotic by more than 30% in any direction, were considered adherent. RESULTS: 69.1% of the patients met the adherence criteria, which was less than that determined by the Drug Attitude Inventory (DAI-10), the Visual Analogue Scale (VAS), and the Clinician Rating Scale (CRS). 7.3% of the patients took less than 80% of the prescribed doses and a change in blood concentrations of the antipsychotic by more than 30% was detected in 25.4% of the patients. In 70.9% of patients, the detected concentrations were within the recommended therapeutic reference interval. The groups of adherent and non-adherent patients did not differ statistically significantly in the severity of their illness as determined by the Clinical Global Impression (CGI), the Personal and Social Performance scale (PSP), and the Positive and Negative Syndrome Scale (PANSS). CONCLUSIONS: The combined method of evaluating adherence in schizophrenia patients confirmed the results determined by other methods. The benefits of this approach are described in the paper.

• MeSH
• adherence k farmakoterapii * psychologie   MeSH
• antipsychotika * krev   terapeutické užití   MeSH
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• monitorování léčiv * metody   MeSH
• prospektivní studie MeSH
• schizofrenie * farmakoterapie   krev   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

Studie RELIEF byla mezinárodní, observační, prospektivní a neintervenční, zahrnovala Českou republiku, Bosnu a Hercegovinu, Srbsko, Severní Makedonii a Chorvatsko. Bylo do ní zařazeno 4 496 pacientů ve 328 centrech. Cílem bylo sledovat pacienty s bolestí vyžadující léčbu NSAID a/nebo lékem tramadol/paracetamol a zároveň zhodnotit přítomnost rizikových faktorů ovlivňujících volbu analgetické terapie. Tento článek se zaměřuje na data z České republiky. Cíl práce. Hlavním cílem studie bylo zjistit, zda a jak určují volbu analgetické léčby (NSAID a/nebo kombinací tramadol/paracetamol) pro pacienta specifické rizikové faktory (gastrointestinální, kardiovaskulární, renální a jaterní), intenzita, typ a trvání bolesti. Navíc se studie zaměřila na vliv bolesti a vliv odpovídající zvolené léčby na kvalitu pacientova života (mobilitu, běžné aktivity, společenský život, spánek a náladu). Metodika. V ČR bylo do studie zařazeno 570 pacientů (43 % mužů, 57 % žen, průměrný věk 62,1 ± 15,4 let). Akutní bolest (< 3 měsíce) mělo 37,5 % pacientů, chronickou (> 3 měsíce) 62,5 %. Údaje byly sbírány ve dvou časových bodech, druhý sběr proběhl po 12 ± 2 týdnech. Výsledky. Při 1. sběru dat bylo 78,2 % pacientů již léčeno analgetiky, nejčastěji ibuprofenem (22,2 %), tramadolem/paracetamolem (20,6 %) a diklofenakem (13,0 %). Rizikové faktory mělo 62,5 % pacientů, nejčastěji kardiovaskulární (57,2 %), což odpovídá obecně uváděným statistikám v populaci. Průměrná intenzita bolesti na VAS byla 64,4 ± 16,1 mm. Po 12 týdnech bylo 86,4 % pacientů s léčbou spokojeno; lékaři vyhodnotili zlepšení u 74,6 % pacientů. Nežádoucí účinky se vyskytly u 1,1 % pacientů. Závěr. Studie ukázala vysoký podíl pacientů s chronickou bolestí a časté užívání NSAID a kombinace léků tramadol/paracetamol. Po 12 týdnech léčby byla zaznamenána vysoká míra spokojenosti a klinického zlepšení. Zároveň bylo potvrzeno, že významná část pacientů měla kardiovaskulární nebo jiné rizikové faktory, což podtrhuje nutnost pečlivého individuálního zvažování analgetické terapie s ohledem na bezpečnost a optimalizaci léčby.

RELIEF study was an international, observational, prospective, and non-interventional study conducted in the Czech Republic, Bosnia and Herzegovina, Serbia, North Macedonia, and Croatia. A total of 4.496 patients from 328 centers were included. The study aimed to monitor patients with pain requiring treatment with NSAIDs and/or tramadol/paracetamol while also assessing the presence of risk factors influencing analgesic therapy selection. This article focuses on data from the Czech Republic. Major statement. The main study objective is to find out if and how patient-specific risk factors (gastrointestinal, cardiovascular, renal and hepatic), intensity, type and duration of pain determine the choice of analgesic treatment, such as NSAIDs and/or tramadol/paracetamol combination. Additionally, we will also focus on the influence of pain and corresponding treatment choices on quality of life (mobility, usual life, social life, sleep and mood). Methods. In the Czech Republic, 570 patients were enrolled (43% men, 57% women, mean age 62.1 ± 15.4 years). Acute pain (<3 months) was reported in 37.5% of patients, while 62.5% suffered from chronic pain (>3 months). Data were collected at two time points, with the second collection occurring after 12 ± 2 weeks. Results. At the first data collection, 78.2 % of patients were already receiving analgesic treatment, most commonly ibuprofen (22.2 %), tramadol/paraceta- mol (20.6 %), and diclofenac (13.0 %). Risk factors were present in 62.5 % of patients, most frequently cardiovascular (57.2 %), which aligns with general population statistics. The average pain intensity on the VAS scale was 64.4 ± 16.1 mm. After 12 weeks, 86.4 % of patients were satisfied with their treatment, and physicians reported improvement in 74.6 % of cases. Adverse effects were observed in 1.1 % of patients. Conclusion. The study highlighted a high prevalence of chronic pain and frequent use of NSAIDs and the tramadol/paracetamol combination. After 12 weeks of treatment, a high level of patient satisfaction and clinical improvement was observed. Additionally, asignificant proportion of patients had cardiovascular or other risk factors, emphasizing the need for careful, individualized consideration of analgesic therapy to ensure both safety and treatment optimizati

• Klíčová slova
• studie RELIEF,
• MeSH
• antiflogistika nesteroidní terapeutické užití   MeSH
• bolest * farmakoterapie   MeSH
• kombinovaná farmakoterapie MeSH
• kvalita života MeSH
• lidé středního věku MeSH
• lidé MeSH
• měření bolesti MeSH
• neopioidní analgetika MeSH
• opioidní analgetika MeSH
• paracetamol terapeutické užití   MeSH
• pozorovací studie jako téma MeSH
• prospektivní studie MeSH
• rizikové faktory MeSH
• senioři MeSH
• tramadol terapeutické užití   MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• přehledy MeSH
• Geografické názvy
• Česká republika MeSH

BACKGROUND: Alpha-mannosidosis is a rare recessive lysosomal storage disorder with progressive multi-systemic impacts. In the absence of standardized monitoring protocols, there is insufficient understanding of disease progression over time. This study explored the evolution of the burden of illness and quality of life (QoL) experienced by patients with alpha-mannosidosis via an international patient and caregiver-based survey. The online survey was distributed to adult patients/caregivers of patients ≥ 10 years old. It included visual analogue scales (VAS; timepoints 5 years ago and now), multiple choice, and open text questions. We report a subset of functional and QoL data: walking ability, pain/discomfort, ability to self-care, and mental health. RESULTS: Analyses include 51 responses from 18 countries: 26 patients were on velmanase alfa enzyme replacement therapy (ERT), seven had been treated with hematopoietic stem cell transplantation (HSCT) and 18 were untreated patients (UP). Over 5 years, VAS scores showed the least decline in walking ability for HSCT patients (+ 0.1 ± 1.9) compared to patients receiving ERT (+ 0.7 ± 1.2) and UP (+ 1.8 ± 2.0). A trend towards improvement in pain was only observed for those on ERT (-0.2 ± 2.0), both for pediatric and adult patients. Ability to self-care improved for patients treated with HSCT (-1.0 ± 1.8) and slightly improved with ERT (-0.3 ± 1.5) but worsened for UP (+ 0.6 ± 0.9). Similarly, a trend towards improvement in mental health scores was observed for patients on ERT (-0.4 ± 2.2). CONCLUSIONS: Alpha-mannosidosis is associated with a substantial and progressive burden in UP, including deterioration in walking ability, pain, self-care and mental health. The survey results suggest that treatment with ERT or HSCT may slow this natural progression of alpha-mannosidosis, with these patients following a different disease trajectory to those solely receiving supportive care. This study could inform the natural pathway of alpha-mannosidosis to recognize patients' needs, courses of care, and the design of interventional studies.

• MeSH
• alfa-mannosidóza * patofyziologie   terapie   MeSH
• bolest * patofyziologie   MeSH
• dospělí MeSH
• duševní zdraví MeSH
• enzymová substituční terapie MeSH
• kvalita života MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• osoby pečující o pacienty MeSH
• péče o sebe MeSH
• průzkumy a dotazníky MeSH
• transplantace hematopoetických kmenových buněk MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

OBJECTIVES: Chronic back pain is the most common cause of incapacity for work. The purpose of the study was to determine the effectiveness for activating the function of the deep stabilization system (DSS) in patients with chronic low back pain. METHODS: The effectiveness of three different methods was compared: Pilates method (PM), dynamic neuromuscular stabilization and balance aids on deep stabilization system function and pain perception in the lumbar spine. The group consisted of 75 patients. RESULTS: The results show differences in the effectiveness of the methods depending on the observed characteristics. The least significant differences were observed when comparing the Pilates method to balance aids. No statistically significant difference was observed in four out of five areas. The only area where a statistically significant effect of the exercise method got recorded was the intra-abdominal pressure test (p < 0.05). The lowest change was recorded in the measured values using the intra-abdominal pressure test at PM, and the highest change was recorded in Thomayer's values at dynamic neuromuscular stabilization. CONCLUSION: By comparing the three methods it was noted that each of them has its own positive reaction to the pain and the muscular apparatus. The most appropriate method to affect DSS function appears the dynamic neuromuscular stabilization (DNS) concept, where was the most significant improvement in DSS activation and the most significant reduction in chronic low back pain.

• MeSH
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• lumbalgie * terapie   rehabilitace   patofyziologie   MeSH
• měření bolesti MeSH
• techniky cvičení a pohybu * metody   MeSH
• terapie cvičením * metody   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

INTRODUCTION: The retrospective study evaluated the clinical and radiological outcomes of conservative treatment for type II odontoid C2 fractures in octogenerians. The study aimed to assess the clinical outcomes and quality of survival of patients treated using conservative methods. Additionally, the study sought to define radiological outcomes, fracture healing success and the development of complications in correlation with clinical outcomes. MATERIALS AND METHODS: Patients aged ≥80 with dens C2 fracture were fixed with a hard cervical collar for 6 weeks, followed by early mobilization. Patients showing delayed fracture healing on computed tomography (CT) scan were subsequently immobilized in a soft neck collar for additional 6 weeks. The follow-up CT scan was then performed with consequential rehabilitation. Patients with nonunion of the C2 on the follow-up CT scan and clinical symptoms were contraindicated for physical rehabilitation for cervical spine till next CT scan after another 12 weeks. Clinical and radiographic evaluations were performed during follow-up visits, with a median follow-up was 109 days, with the range extending from 1 day to 1 year. RESULTS: In total, 33 patients were included in the study and were followed for 1 year. The 30-day mortality rate was 21.2%, and between 30 days and one year post-treatment, it was 18.2%. Mortality was higher during the study period in displaced fractures (>2 mm; 9 out of 16 patients died) compared to non-displaced fractures (≤2 mm; 4 out of 17 patients died). The Japanese Orthopaedic Association (JOA) score remained unchanged between admission (mean 16.9; SD ± 0.5) and the end of follow-up (mean 16.9; SD ± 0.5; P > 0.05), the Visual Analogue Scale (VAS) score showed improvement from values measured upon admission to the hospital (mean 7.97; SD ± 1.33) to values measured at the end of follow-up (mean 1.58; SD ± 1.62; P < 0.001) and the Neck Disability Index (NDI) showed a statistically significant difference between admission (mean 41.3; SD ± 14.92) and the end of follow-up (mean 14.29; SD ± 4.65; P < 0.001). The standard measurement of Posterior Atlantodental Interval (PADI) had an average value of 18.6 (range 16-22 mm) and primary bony union of odontoid fractures occurred in eleven cases (33.3%), while six patients (18.2%) had fibrous union with minimal clinical difficulties. CONCLUSION: This study demonstrates the safety and efficacy of conservative treatment for odontoid fractures in octogenerians and underscores the critical role of conservative management in a polymorbid elderly population.

• Publikační typ
• časopisecké články MeSH

BACKGROUND: Adherence to rhinitis treatment has been insufficiently assessed. We aimed to use data from the MASK-air mHealth app to assess adherence to oral antihistamines (OAH), intra-nasal corticosteroids (INCS) or azelastine-fluticasone in patients with allergic rhinitis. METHODS: We included regular European MASK-air users with self-reported allergic rhinitis and reporting at least 1 day of OAH, INCS or azelastine-fluticasone. We assessed weeks during which patients answered the MASK-air questionnaire on all days. We restricted our analyses to data provided between January and June, to encompass the pollen seasons across the different assessed countries. We analysed symptoms using visual analogue scales (VASs) and the combined symptom-medication score (CSMS), performing stratified analyses by weekly adherence levels. Medication adherence was computed as the proportion of days in which patients reported rhinitis medication use. Sensitivity analyses were performed considering all weeks with at most 1 day of missing data and all months with at most 4 days of missing data. RESULTS: We assessed 8212 complete weeks (1361 users). Adherence (use of medication > 80% days) to specific drug classes ranged from 31.7% weeks for azelastine-fluticasone to 38.5% weeks for OAH. Similar adherence to rhinitis medication was found in users with or without self-reported asthma, except for INCS (better adherence in asthma patients). VAS and CSMS levels increased from no adherence to full adherence, except for INCS. A higher proportion of days with uncontrolled symptoms was observed in weeks with higher adherence. In full adherence weeks, 41.2% days reported rhinitis co-medication. The sensitivity analyses displayed similar results. CONCLUSIONS: A high adherence was found in patients reporting regular use of MASK-air. Different adherence patterns were found for INCS compared to OAH or azelastine-fluticasone that are likely to impact guidelines.

• MeSH
• adherence k farmakoterapii * MeSH
• antialergika terapeutické užití   MeSH
• antihistaminika terapeutické užití   MeSH
• dospělí MeSH
• flutikason terapeutické užití   aplikace a dávkování   MeSH
• ftalaziny terapeutické užití   MeSH
• hormony kůry nadledvin terapeutické užití   aplikace a dávkování   MeSH
• lidé středního věku MeSH
• lidé MeSH
• průzkumy a dotazníky MeSH
• pyl imunologie   MeSH
• roční období * MeSH
• sezónní alergická rýma * farmakoterapie   epidemiologie   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Evropa MeSH

BACKGROUND: Back pain is a common but often underestimated symptom of patients with MS that can negatively influence their quality of life. However there are only limited number of studies comparing the effect of different types of exercise and use of telerehabilitation on back pain in MS. Therefore, the aim of the study is to compare whether telerehabilitation alone is as effective as conventional outpatient physiotherapy followed by online exercise. METHODS: This single-centre intervention study compared the impact of different individual outpatient physiotherapy treatments (Group 1 - individual Pilates exercise or Group 2 - strength training) and telerehabilitation alone (individual Pilates exercise with a physiotherapist online). The primary objective was to compare the effect of interventions on back pain (assessed using the Visual Analogue Scale and McGill Pain Questionnaire) and quality of life (Multiple Sclerosis Quality of Life-54). Secondary aims were to compare effect of interventions on spine and thorax mobility, functional mobility (assessed using the Timed 25 foot walk test, Six Spot Step test), respiratory muscle strenght and patient reported outcomes (assessed using he Hospital Anxiety and Depression Scale, Fatigue Severity Scale). RESULTS: 45 people with MS were enrolled in the study (3 men, age:48.4± SD 11,5, Expanded Disability Status Scale (EDSS): 3.3±SD 1,1) and 36 people completed the entire exercise program. All types of exercise intervention showed a positive effect on the reduction of back pain, quality of life and fatigue. The interventions also increased respiratory muscle strength and increased thorax mobility, but we did not find any effect of interventions on gait tests. There were no difference in effect on outcome measures between different types of exercise interventions. CONCLUSION: Telerehabilitation, involving individual exercise sessions with a physiotherapist, has a comparable effect on reducing back pain, improving quality of life, and enhancing respiratory muscle strength in people with MS as individual Pilates or strength training.

• MeSH
• bolesti zad * rehabilitace   MeSH
• dospělí MeSH
• kvalita života * MeSH
• lidé středního věku MeSH
• lidé MeSH
• odporový trénink metody   MeSH
• roztroušená skleróza * rehabilitace   komplikace   MeSH
• stupeň závažnosti nemoci MeSH
• techniky cvičení a pohybu metody   MeSH
• techniky fyzikální terapie * MeSH
• telerehabilitace * MeSH
• terapie cvičením metody   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

Chronic pain poses a significant global socio-medical challenge causing significant costs. It is only since the mid-20th century that pain syndromes have been considered diseases in their own right. According to the definition of the International Association for the Study of Pain, pain is a complex, context-dependent-and hence modifiable-phenomenon. The philosophical view on pain is no less multi-facetted and allows for a wide range of viewpoints. This analysis aims at a characterisation of pain including a-mainly phenomenological and enactivist-philosophical perspective. The discourse will be guided by the concept of the limit(s) of the lived body: what is the relationship between pain and the perception of the lived body's boundaries? Does a reciprocal influence exist? And may the perception be modified in order to reduce the patient's suffering? These musings will also clarify that neurosciences and philosophy are not competing sciences, but rather inform each other.

• MeSH
• chronická bolest * psychologie   MeSH
• filosofie lékařská MeSH
• lidé MeSH
• měření bolesti MeSH
• percepce bolesti fyziologie   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• přehledy MeSH