G-quadruplex, Friend or Foe: The Role of the G-quartet in Anticancer Strategies
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
32467069
DOI
10.1016/j.molmed.2020.05.002
PII: S1471-4914(20)30131-3
Knihovny.cz E-resources
- Keywords
- G-quadruplex, anticancer strategy, aptamers, cell regulation, drug discovery, ligands,
- MeSH
- Aptamers, Nucleotide pharmacology therapeutic use MeSH
- G-Quadruplexes drug effects MeSH
- Humans MeSH
- Ligands MeSH
- Neoplasms drug therapy MeSH
- Nucleic Acids pharmacology MeSH
- Oligodeoxyribonucleotides pharmacology therapeutic use MeSH
- Antineoplastic Agents pharmacology therapeutic use MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- AGRO 100 MeSH Browser
- Aptamers, Nucleotide MeSH
- Ligands MeSH
- Nucleic Acids MeSH
- Oligodeoxyribonucleotides MeSH
- Antineoplastic Agents MeSH
The clinical applicability of G-quadruplexes (G4s) as anticancer drugs is currently being evaluated. Several G4 ligands and aptamers are undergoing clinical trials following the notable examples of quarfloxin and AS1411, respectively. In this review, we summarize the latest achievements and breakthroughs in the use of G4 nucleic acids as both therapeutic tools ('friends', as healing anticancer drugs) and targets ('foes', within the harmful cancer cell), particularly using aptamers and quadruplex-targeted ligands, respectively. We explore the recent research on synthetic G4 ligands toward the discovery of anticancer therapeutics and their mechanism of action. Additionally, we highlight recent advances in chemical and structural biology that enable the design of specific G4 aptamers to be used as novel anticancer agents.
References provided by Crossref.org
Complexity of Guanine Quadruplex Unfolding Pathways Revealed by Atomistic Pulling Simulations
G-quadruplex ligands as potent regulators of lysosomes
G-quadruplexes in helminth parasites
G-Quadruplex in Gene Encoding Large Subunit of Plant RNA Polymerase II: A Billion-Year-Old Story
