G-quadruplex, Friend or Foe: The Role of the G-quartet in Anticancer Strategies
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
32467069
DOI
10.1016/j.molmed.2020.05.002
PII: S1471-4914(20)30131-3
Knihovny.cz E-zdroje
- Klíčová slova
- G-quadruplex, anticancer strategy, aptamers, cell regulation, drug discovery, ligands,
- MeSH
- aptamery nukleotidové farmakologie terapeutické užití MeSH
- G-kvadruplexy účinky léků MeSH
- lidé MeSH
- ligandy MeSH
- nádory farmakoterapie MeSH
- nukleové kyseliny farmakologie MeSH
- oligodeoxyribonukleotidy farmakologie terapeutické užití MeSH
- protinádorové látky farmakologie terapeutické užití MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- AGRO 100 MeSH Prohlížeč
- aptamery nukleotidové MeSH
- ligandy MeSH
- nukleové kyseliny MeSH
- oligodeoxyribonukleotidy MeSH
- protinádorové látky MeSH
The clinical applicability of G-quadruplexes (G4s) as anticancer drugs is currently being evaluated. Several G4 ligands and aptamers are undergoing clinical trials following the notable examples of quarfloxin and AS1411, respectively. In this review, we summarize the latest achievements and breakthroughs in the use of G4 nucleic acids as both therapeutic tools ('friends', as healing anticancer drugs) and targets ('foes', within the harmful cancer cell), particularly using aptamers and quadruplex-targeted ligands, respectively. We explore the recent research on synthetic G4 ligands toward the discovery of anticancer therapeutics and their mechanism of action. Additionally, we highlight recent advances in chemical and structural biology that enable the design of specific G4 aptamers to be used as novel anticancer agents.
Citace poskytuje Crossref.org
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