Correlation of Iodine Quantification and FDG Uptake in Early Therapy Response Assessment of Non-small Cell Lung Cancer: Possible Benefit of Dual-energy CT Scan as an Integral Part of PET/CT Examination
Jazyk angličtina Země Řecko Médium print
Typ dokumentu časopisecké články
PubMed
32487645
DOI
10.21873/anticanres.14332
PII: 40/6/3459
Knihovny.cz E-zdroje
- Klíčová slova
- Multidetector computed tomography, dual-energy, fluorodeoxyglucose, iodine, lung cancer, positron-emission tomography,
- MeSH
- adjuvantní chemoterapie MeSH
- dospělí MeSH
- jod MeSH
- lidé středního věku MeSH
- lidé MeSH
- nádory plic diagnóza terapie MeSH
- nemalobuněčný karcinom plic diagnóza terapie MeSH
- PET/CT * metody MeSH
- počítačová rentgenová tomografie * metody MeSH
- radiofarmaka MeSH
- ROC křivka MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- staging nádorů MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- jod MeSH
- radiofarmaka MeSH
AIM: To compare iodine-related and fluorine-18 fluorodeoxyglucose (18F-FDG) parameters during staging of lung cancer as well as during early follow-up, while investigating potential use and possible substitutability in the assessment of therapeutic response or prediction. PATIENTS AND METHODS: Patients (n=45) with confirmed lung cancer underwent 18F-FDG positron-emission tomography (PET) using single-source dual-energy computed tomography was performed for staging and early follow-up. Correlation of FDG uptake and iodine-related parameters was assessed and comparison with therapy response was performed. RESULTS: A strong correlation was found between the volumetric FDG parameters metabolic tumour volume (MTV) and total lesion glycolysis (TLG) and iodine uptake (IU) in staging (IU vs. MTV: rs=0.894; p<0.001 and IU vs. TLG: rs=0.874; p<0.001) and follow-up (IU vs. MTV: rs=0.934, p<0.001 and IU vs. TLG: rs=0.935, p<0.001). We also found significant correlation of change in these values between timepoints. We observed a significant correlation of IU, MTV and TLG with early therapy response and IU was found as a possible strong predictor. CONCLUSION: Strong correlation of IU and volume-based FDG parameters was proved in staging, follow-up and change during therapy. Potential role of IU in prediction of early therapy-response was identified. Our study suggests a significant benefit of using the dual-energy computed tomography as a part of 18F-FDG PET/CT in patients with lung cancer.
Biomedical Center Faculty of Medicine in Pilsen Charles University Pilsen Czech Republic
CT Physics and Application Development Siemens Healthineers Forchheim Germany
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