Correlation of Iodine Quantification and FDG Uptake in Early Therapy Response Assessment of Non-small Cell Lung Cancer: Possible Benefit of Dual-energy CT Scan as an Integral Part of PET/CT Examination
Language English Country Greece Media print
Document type Journal Article
PubMed
32487645
DOI
10.21873/anticanres.14332
PII: 40/6/3459
Knihovny.cz E-resources
- Keywords
- Multidetector computed tomography, dual-energy, fluorodeoxyglucose, iodine, lung cancer, positron-emission tomography,
- MeSH
- Chemotherapy, Adjuvant MeSH
- Adult MeSH
- Iodine MeSH
- Middle Aged MeSH
- Humans MeSH
- Lung Neoplasms diagnosis therapy MeSH
- Carcinoma, Non-Small-Cell Lung diagnosis therapy MeSH
- Positron Emission Tomography Computed Tomography * methods MeSH
- Tomography, X-Ray Computed * methods MeSH
- Radiopharmaceuticals MeSH
- ROC Curve MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Neoplasm Staging MeSH
- Treatment Outcome MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Iodine MeSH
- Radiopharmaceuticals MeSH
AIM: To compare iodine-related and fluorine-18 fluorodeoxyglucose (18F-FDG) parameters during staging of lung cancer as well as during early follow-up, while investigating potential use and possible substitutability in the assessment of therapeutic response or prediction. PATIENTS AND METHODS: Patients (n=45) with confirmed lung cancer underwent 18F-FDG positron-emission tomography (PET) using single-source dual-energy computed tomography was performed for staging and early follow-up. Correlation of FDG uptake and iodine-related parameters was assessed and comparison with therapy response was performed. RESULTS: A strong correlation was found between the volumetric FDG parameters metabolic tumour volume (MTV) and total lesion glycolysis (TLG) and iodine uptake (IU) in staging (IU vs. MTV: rs=0.894; p<0.001 and IU vs. TLG: rs=0.874; p<0.001) and follow-up (IU vs. MTV: rs=0.934, p<0.001 and IU vs. TLG: rs=0.935, p<0.001). We also found significant correlation of change in these values between timepoints. We observed a significant correlation of IU, MTV and TLG with early therapy response and IU was found as a possible strong predictor. CONCLUSION: Strong correlation of IU and volume-based FDG parameters was proved in staging, follow-up and change during therapy. Potential role of IU in prediction of early therapy-response was identified. Our study suggests a significant benefit of using the dual-energy computed tomography as a part of 18F-FDG PET/CT in patients with lung cancer.
Biomedical Center Faculty of Medicine in Pilsen Charles University Pilsen Czech Republic
CT Physics and Application Development Siemens Healthineers Forchheim Germany
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