Three neurosteroids as well as GABAergic drugs do not convert immediate postictal potentiation to depression in immature rats
Jazyk angličtina Země Švýcarsko Médium print-electronic
Typ dokumentu srovnávací studie, časopisecké články
Grantová podpora
CZ_02.1.01/0.0/0.0/16_025/0007444
Ministerstvo Průmyslu a Obchodu (CZ)
18-09296S
Grantová Agentura České republiky (CZ)
PubMed
32515003
DOI
10.1007/s43440-020-00113-2
PII: 10.1007/s43440-020-00113-2
Knihovny.cz E-zdroje
- Klíčová slova
- Cortical afterdischarges, Gabaergic drugs, Immature rats, Neurosteroids, Postictal potentiation,
- MeSH
- antikonvulziva farmakologie MeSH
- časové faktory MeSH
- implantované elektrody MeSH
- krysa rodu Rattus MeSH
- midazolam farmakologie MeSH
- modely nemocí na zvířatech MeSH
- muscimol farmakologie MeSH
- neurosteroidy farmakologie MeSH
- potkani Wistar MeSH
- receptory GABA-A účinky léků metabolismus MeSH
- záchvaty farmakoterapie MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
- Názvy látek
- antikonvulziva MeSH
- midazolam MeSH
- muscimol MeSH
- neurosteroidy MeSH
- receptory GABA-A MeSH
BACKGROUND: Postictal potentiation presented immediately after cortical seizures in immature rats might be due to imbalance between excitation and inhibition. The aim of the present study was to determine whether augmentation of inhibition mediated by GABAA receptors could also suppress the postictal potentiation. METHODS: Twelve-day old rats with implanted electrodes were used in our study. Five drugs were tested: the agonist muscimol, the positive modulator midazolam and three neurosteroids affecting GABAA receptors-allopregnanolone, pregnanolone sulphate and pregnanolone glutamate. RESULTS: None of the five drugs was able to suppress potentiation appearing immediately after cortical epileptic afterdischarges, but all of them exhibited delayed anticonvulsant action 10 (in the case of midazolam and muscimol) or 20 min (all three steroids) after cortical seizures. CONCLUSION: Our results support a role of GABA in augmentation of cortical after discharges after longer intervals, whereas immediate postictal potentiation is not affected by GABAergic drugs. Due to similar effect with GABAergic drugs, the main mechanism of action of the three steroids tested is potentiation of GABAergic inhibition.
Institute of Organic Chemistry and Biochemistry Czech Academy of Sciences Prague Czech Republic
Institute of Physiology Czech Academy of Sciences Prague Czech Republic
Citace poskytuje Crossref.org
Epilepsy Research in the Institute of Physiology of the Czech Academy of Sciences in Prague
