A massive systematic infection of Encephalitozoon cuniculi genotype III in mice does not cause clinical signs
Jazyk angličtina Země Francie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
32579904
DOI
10.1016/j.micinf.2020.06.004
PII: S1286-4579(20)30122-2
Knihovny.cz E-zdroje
- Klíčová slova
- Albendazole, C57Bl/6 mice, CD4(−/−) mice, CD8(−/−) mice, Encephalitozoon cuniculi genotype III,
- MeSH
- albendazol terapeutické užití MeSH
- antigeny CD4 genetika MeSH
- antigeny CD8 genetika MeSH
- Cercopithecus aethiops MeSH
- Encephalitozoon cuniculi genetika MeSH
- encephalitozoonóza farmakoterapie mikrobiologie patologie MeSH
- genotyp * MeSH
- modely nemocí na zvířatech MeSH
- myši inbrední C57BL MeSH
- myši MeSH
- Vero buňky MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- albendazol MeSH
- antigeny CD4 MeSH
- antigeny CD8 MeSH
Encephalitozoon cuniculi genotype III disseminated intensively into most of the organs in all strains of mice, followed by a chronic infection with massive microsporidia persistence in immunodeficient mice and a partial decrease in C57Bl/6 mice. Treatment with 0.2 mg Albendazole/mouse/day temporarily reduces the number of affected organs in immunocompetent C57Bl/6 mice, but not in CD4-/- and CD8-/- mice. The application of medication temporarily decreased the spore burden at least by one order of magnitude in all groups. These results demonstrate that the E. cuniculi genotype III infection had a progressive course and surprisingly, Albendazole treatment had only a minimal effect. The E. cuniculi genotype III spore burden in individual organs reached up to 108 or 109 in immunocompetent or immunodeficient mice, respectively; however, these mice did not demonstrate any obvious clinical signs of microsporidiosis, and the immunodeficient mice survived longer. Our findings clearly show that the survival of mice does not correspond to spore burden, which provides new insight into latent microsporidiosis from an epidemiological point of view.
Citace poskytuje Crossref.org
Chronic Infections in Mammals Due to Microsporidia
