Zobrazit více v PubMed
Engstrom W, Shokrai A, Otte K, Granerus M, Gessbo A, Bierke P, et al. Transcriptional regulation and biological significance of the insulin like growth factor II gene. Cell Prolif, 1998. 31(5–6): p. 173–89 10.1111/j.1365-2184.1998.tb01196.x
PubMed
DOI
PMC
Efstratiadis A. Genetics of mouse growth. Int J Dev Biol. 1998;42(7):955–76. PMID: ISI:000076795600017.
PubMed
Eggenschwiler J, Ludwig T, Fisher P, Leighton PA, Tilghman SM, Efstratiadis A. Mouse mutant embryos overexpressing IGF-II exhibit phenotypic features of the Beckwith-Wiedemann and Simpson-Golabi-Behmel syndromes. Genes & Development. 1997;11(23):3128–42. 10.1101/gad.11.23.3128 PMID: ISI:A1997YL52600004.
PubMed
DOI
PMC
Livingstone C. IGF2 and cancer. Endocr-Relat Cancer, 2013. 20(6): p. R321–R39 10.1530/ERC-13-0231
PubMed
DOI
LeRoith D, Roberts CT. The insulin-like growth factor system and cancer. Cancer Lett, 2003. 195(2): p. 127–37 10.1016/s0304-3835(03)00159-9
PubMed
DOI
Dynkevich Y, Rother KI, Whitford I, Qureshi S, Galiveeti S, Szulc AL, et al. Tumors, IGF-2, and Hypoglycemia: Insights From the Clinic, the Laboratory, and the Historical Archive. Endocr Rev, 2013. 34(6): p. 798–826. 10.1210/er.2012-1033
PubMed
DOI
Giannoukakis N, Deal C, Paquette J, Goodyer CG, Polychronakos C. Parental Genomic Imprinting of the Human Igf2 Gene. Nature Gen, 1993. 4(1): p. 98–101. 10.1038/Ng0593-98
PubMed
DOI
Alberini CM, Chen DY. Memory enhancement: consolidation, reconsolidation and insulin-like growth factor 2. Trends Neurosci, 2012. 35(5): p. 274–83. 10.1016/j.tins.2011.12.007
PubMed
DOI
PMC
Chen DY, Stern SA, Garcia-Osta A, Saunier-Rebori B, Pollonini G, Bambah-Mukku D, et al. A critical role for IGF-II in memory consolidation and enhancement. Nature, 2011. 469(7331): p. 491–7. 10.1038/nature09667
PubMed
DOI
PMC
Steinmetz AB, Johnson SA, Iannitelli DE, Pollonini G, Alberini CM. Insulin-like growth factor 2 rescues aging-related memory loss in rats. Neurobiol Aging, 2016. 44: p. 9–21. 10.1016/j.neurobiolaging.2016.04.006
PubMed
DOI
PMC
Kitraki E, Bozas E, Philippidis H, Stylianopoulou F. Aging-Related Changes in Igf-Ii and C-Fos Gene-Expression in the Rat-Brain. Int J Dev Neurosci, 1993. 11(1): p. 1–9. 10.1016/0736-5748(93)90029-d
PubMed
DOI
Stern SA, Chen DY, Alberini CM. The effect of insulin and insulin-like growth factors on hippocampus- and amygdala-dependent long-term memory formation. Learn Mem, 2014. 21(10): p. 556–63. 10.1101/lm.029348.112
PubMed
DOI
PMC
Pascual-Lucas M, da Silva SV, Di Scala M, Garcia-Barroso C, Gonzalez-Aseguinolaza G, Mulle C, et al. Insulin-like growth factor 2 reverses memory and synaptic deficits in APP transgenic mice. EMBO Mol Med, 2014. 6(10): p. 1246–62. 10.15252/emmm.201404228
PubMed
DOI
PMC
Trenker R, Jura N. Receptor tyrosine kinase activation: From the ligand perspective. Curr Opin Cell Biol, 2020. 63: p. 174–85. 10.1016/j.ceb.2020.01.016
PubMed
DOI
PMC
Clemmons DR. Role of insulin-like growth factor binding proteins in controlling IGF actions. Mol Cell Endocrinol, 1998. 140(1–2): p. 19–24. 10.1016/s0303-7207(98)00024-0
PubMed
DOI
Delaine C, Alvino CL, McNeil KA, Mulhern TD, Gauguin L, De Meyts P, et al. A novel binding site for the human insulin-like growth factor-II (IGF-II)/mannose 6-phosphate receptor on IGF-II. J Biol Chem, 2007. 282(26): p. 18886–94. 10.1074/jbc.M700531200
PubMed
DOI
Lobel P, Dahms NM, Kornfeld S. Cloning and Sequence-Analysis of the Cation-Independent Mannose 6-Phosphate Receptor. J Biol Chem, 1988. 263(5): p. 2563–70.
PubMed
Dahms NM, Hancock MK. P-type lectins. BBA-Gen Subjects, 2002. 1572(2–3): p. 317–40. 10.1016/S0304-4165(02)00317-3
PubMed
DOI
Hassan AB. Keys to the hidden treasures of the mannose 6-phosphate/insulin-like growth factor 2 receptor. Am J Pathol, 2003. 162(1): p. 3–6. 10.1016/S0002-9440(10)63791-1
PubMed
DOI
PMC
Dahms NM. Insulin-like growth factor II cation-independent mannose 6-phosphate receptor and lysosomal enzyme recognition. Biochem Soc Trans, 1996. 24(1): p. 136–41. 10.1042/bst0240136
PubMed
DOI
Linnell J, Groeger G, Hassan AB. Real time kinetics of insulin-like growth factor II (IGF-II) interaction with the IGF-II/mannose 6-phosphate receptor—The effects of domain 13 and pH. J Biol Chem, 2001. 276(26): p. 23986–91. 10.1074/jbc.M100700200
PubMed
DOI
Hartman MA, Kreiling JL, Byrd JC, MacDonald RG. High-affinity ligand binding by wild-type/mutant heteromeric complexes of the mannose 6-phosphate/insulin-like growth factor II receptor. FEBS J, 2009. 276(7): p.1915–29. 10.1111/j.1742-4658.2009.06917.x
PubMed
DOI
PMC
Brown J, Esnouf RM, Jones MA, Linnell J, Harlos K, Hassan AB, et al. Structure of a functional IGF2R fragment determined from the anomalous scattering of sulfur. EMBO J, 2002. 21(5): p. 1054–62. 10.1093/emboj/21.5.1054
PubMed
DOI
PMC
Brown J, Delaine C, Zaccheo OJ, Siebold C, Gilbert RJ, van Boxel G, et al. Structure and functional analysis of the IGF-II/IGF2R interaction. EMBO J, 2008. 27(1): p. 265–76. 10.1038/sj.emboj.7601938
PubMed
DOI
PMC
Frago S, Nicholls RD, Strickland M, Hughes J, Williams C, Garner L, et al. Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist. Proc Natl Acad Sci USA, 2016. 113(20): p. E2766–E75. 10.1073/pnas.1513023113
PubMed
DOI
PMC
Williams C, Hoppe HJ, Rezgui D, Strickland M, Forbes BE, Grutzner F, et al. An Exon Splice Enhancer Primes IGF2:IGF2R Binding Site Structure and Function Evolution. Science, 2012. 338(6111): p. 1209–13. 10.1126/science.1228633
PubMed
DOI
PMC
Ghosh P, Dahms NM, Kornfeld S. Mannose 6-phosphate receptors: New twists in the tale. Nat Rev Mol Cell Biol, 2003. 4(3): p. 202–12. 10.1038/nrm1050
PubMed
DOI
Hawkes C, Kar S. The insulin-like growth factor-II/mannose-6-phosphate receptor: structure, distribution and function in the central nervous system. Brain Res Rev, 2004. 44(2–3): p. 117–40. 10.1016/j.brainresrev.2003.11.002
PubMed
DOI
Dell'Angelica EC, Payne GS. Intracellular cycling of lysosomal enzyme receptors: Cytoplasmic tails' tales. Cell, 2001. 106(4): p. 395–8. 10.1016/s0092-8674(01)00470-6
PubMed
DOI
Byrd JC, Park JHY, Schaffer BS, Garmroudi F, MacDonald RG. Dimerization of the insulin-like growth factor II/mannose 6-phosphate receptor. J Biol Chem, 2000. 275(25): p. 18647–56. 10.1074/jbc.M001273200
PubMed
DOI
Hebert E. Mannose-6-phosphate/Insulin-like growth factor II receptor expression and tumor development. Biosci Rep, 2006. 26(1): p. 7–17. 10.1007/s10540-006-9002-3
PubMed
DOI
Ou JM, Lian WS, Qiu MK, Dai YX, Dong Q, Shen J, et al. Knockdown of IGF2R suppresses proliferation and induces apoptosis in hemangioma cells in vitro and in vivo. Int J Oncol, 2014. 45(3): p. 1241–9. 10.3892/ijo.2014.2512
PubMed
DOI
Sacha P, Knedlik T, Schimer J, Tykvart J, Parolek J, Navratil V, et al. iBodies: Modular Synthetic Antibody Mimetics Based on Hydrophilic Polymers Decorated with Functional Moieties. Angew Chem Int Ed Engl, 2016. 55(7): p. 2356–60. 10.1002/anie.201508642
PubMed
DOI
PMC
Dahms NM, Lobel P, Kornfeld S. Mannose 6-Phosphate Receptors and Lysosomal-Enzyme Targeting. J Biol Chem, 1989. 264(21): p. 12115–8.
PubMed
Braulke T, Tippmer S, Chao HJ, Vonfigura K. Regulation of Mannose 6-Phosphate Insulin-Like Growth Factor-Ii Receptor Distribution by Activators and Inhibitors of Protein Kinase-C. Eur J Biochem, 1990. 189(3): p. 609–16. 10.1111/j.1432-1033.1990.tb15529.x
PubMed
DOI
Jones JI, Clemmons DR. Insulin-Like Growth-Factors and Their Binding-Proteins—Biological Actions. Endocr Rev, 1995. 16(1): p. 3–34. 10.1210/edrv-16-1-3
PubMed
DOI
Murayama Y, Okamoto T, Ogata E, Asano T, Iiri T, Katada T, et al. Distinctive Regulation of the Functional Linkage between the Human Cation-Independent Mannose 6-Phosphate Receptor and Gtp-Binding Proteins by Insulin-Like Growth Factor-Ii and Mannose 6-Phosphate. J Biol Chem, 1990. 265(29): p. 17456–62.
PubMed
Tally M, Hall K. Insulin-Like Growth Factor-Ii Effects Mediated through Insulin-Like Growth Factor-Ii Receptors. Acta Paediatr Scand, 1990: p. 67–75. PubMed PMID: ISI:A1990DQ39200014.
PubMed
El-Shewy HM, Lee MH, Obeid LM, Jaffa AA, Luttrell LM. The insulin-like growth factor type 1 and insulin-like growth factor type 2/Mannose-6-phosphate receptors independently regulate ERK1/2 activity in HEK293 cells. J Biol Chem, 2007. 282(36): p. 26150–7. 10.1074/jbc.M703276200 PubMed PMID: ISI:000249239600018.
PubMed
DOI
De Meyts P. Insulin and growth hormone receptors in human cultured lymphocytes and peripheral blood monocytes. Methods Receptor Res, 1976. 1: p. 301–83
Zakova L, Kletvíková E., Lepšík M., Collinsová M., Watson C. J., Turkenburg J.P., et al. Human insulin analogues modified at the B26 site reveal a hormone conformation that is undetected in the receptor complex. Acta Crystallogr D, 2014. D70: p. 2765–74. 10.1107/S1399004714017775
PubMed
DOI
PMC
Kosinova L, Veverka V, Novotna P, Collinsova M, Urbanova M, Moody NR, et al. Insight into the Structural and Biological Relevance of the T/R Transition of the N-Terminus of the B-Chain in Human Insulin. Biochemistry, 2014. 53(21): p. 3392–402. 10.1021/bi500073z
PubMed
DOI
PMC
Vikova J, Collinsova M, Kletvikova E, Budesinsky M, Kaplan V, Zakova L, et al. Rational steering of insulin binding specificity by intra-chain chemical crosslinking. Sci Rep, 2016. 6: 19431 10.1038/srep19431
PubMed
DOI
PMC
Krizkova K, Chrudinova M, Povalova A, Selicharova I, Collinsova M, Vanek V, et al. Insulin-Insulin-like Growth Factors Hybrids as Molecular Probes of Hormone:Receptor Binding Specificity. Biochemistry. 2016, 55(21): p. 2903–13. 10.1021/acs.biochem.6b00140
PubMed
DOI
Machackova K, Collinsova M, Chrudinova M, Selicharova I, Picha J, Budesinsky M, et al. Insulin-like Growth Factor 1 Analogs Clicked in the C Domain: Chemical Synthesis and Biological Activities. J Med Chem. 2017;60(24):10105–17. 10.1021/acs.jmedchem.7b01331 PubMed PMID: ISI:000419263400013.
PubMed
DOI
Machackova K, Chrudinova M, Radosavljevic J, Potalitsyn P, Krizkova K, Fabry M, et al. Converting Insulin-like Growth Factors 1 and 2 into High-Affinity Ligands for Insulin Receptor Isoform A by the Introduction of an Evolutionarily Divergent Mutation. Biochemistry, 2018. 57(16): p. 2373–82. 10.1021/acs.biochem.7b01260
PubMed
DOI
Chrudinova M, Zakova L, Marek A, Socha O, Budesinsky M, Hubalek M, et al. A versatile insulin analog with high potency for both insulin and insulin-like growth factor 1 receptors: Structural implications for receptor binding. J Biol Chem, 2018. 293(43): p. 16818–29. 10.1074/jbc.RA118.004852
PubMed
DOI
PMC
Machackova K, Mlcochova K, Potalitsyn P, Hankova K, Socha O, Budesinski M, et al. Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2 result in receptor- and hormone-specific responses. J Biol Chem, 2019. 294(46): p. 17371–82. 10.1074/jbc.RA119.010072
PubMed
DOI
PMC
Schneider A, Hanke W. Influence of insulin-like growth factors and insulin on the [S-35]sulfate uptake by cartilage of the axolotl (Ambystoma mexicanum). Gen Comp Endocrinol, 1996. 104(1): p. 92–102. 10.1006/gcen.1996.0145
PubMed
DOI
Sakano KI, Enjoh T, Numata F, Fujiwara H, Marumoto Y, Higashihashi N, et al. The Design, Expression, and Characterization of Human Insulin-Like Growth Factor-II (IGF-II) Mutants Specific for Either the IGF-II Cation-Independent Mannose 6-Phosphate Receptor or IGF-I Receptor. J Biol Chem, 1991. 266(31): p. 20626–35.
PubMed
Roth BV, Burgisser DM, Luthi C, Humbel RE. Mutants of Human Insulin-Like Growth Factor-II—Expression and Characterization of Analogs with a Substitution of Tyr27 and or a Deletion of Residues 62–67. Biochem Biophys Res Commun, 1991. 181(2): p. 907–14. 10.1016/0006-291x(91)91277-j
PubMed
DOI
Burgisser DM, Roth BV, Giger R, Luthi C, Weigl S, Zarn J, et al. Mutants of Human Insulin-Like Growth Factor-Ii with Altered Affinities for the Type-1 and Type-2 Insulin-Like Growth-Factor Receptor. J Biol Chem, 1991. 266(2): p. 1029–33.
PubMed
Zaccheo OJ, Prince SN, Miller DM, Williams C, Kemp CF, Brown J, et al. Kinetics of insulin-like growth factor II (IGF-II) interaction with domain 11 of the human IGF-II/mannose 6-phosphate receptor: Function of CD and AB loop solvent-exposed residues. J Mol Biol, 2006. 359(2): p. 403–21. 10.1016/j.jmb.2006.03.046
PubMed
DOI
Williams C, Rezgui D, Prince SN, Zaccheo OJ, Foulstone EJ, Forbes BE, et al. Structural insights into the interaction of insulin-like growth factor 2 with IGF2R domain 11. Structure, 2007. 15(9): p. 1065–78. 10.1016/j.str.2007.07.007
PubMed
DOI
Hexnerova R, Krizkova K, Fabry M, Sieglova I, Kedrova K, Collinsova M, et al. Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain. J Biol Chem, 2016. 291(40): p. 21234–45. 10.1074/jbc.M116.741041
PubMed
DOI
PMC
Elbert T, Vesela I. Conditions for Succsesful Labeling of Oxidation Sensitive Peptides by Na[I-125]—Iodo-Gen (Tm) System. J Labelled Compd Rad, 2010. 53(5–6): p. 288–91. 10.1002/jlcr.1765
DOI
Slaaby R, Andersen AS, Brandt J. IGF-I binding to the IGF-I receptor is affected by contaminants in commercial BSA: The contaminants are proteins with IGF-I binding properties. Growth Horm IGF Res, 2008. 18(4): p. 267–74. 10.1016/j.ghir.2007.09.003
PubMed
DOI
Morcavallo A, Genua M, Palummo A, Kletvikova E, Jiracek J, Brzozowski AM, et al. Insulin and Insulin-like Growth Factor II Differentially Regulate Endocytic Sorting and Stability of Insulin Receptor Isoform A. J Biol Chem, 2012. 287(14): p. 11422–36. 10.1074/jbc.M111.252478
PubMed
DOI
PMC
Fernandez AM, Torres-Aleman I. The many faces of insulin-like peptide signalling in the brain. Nat Rev Neurosci, 2012. 13(4): p. 225–39. 10.1038/nrn3209
PubMed
DOI
Kar S, Chabot JG, Quirion R. Quantitative Autoradiographic Localization of [I-125] Insulin-Like Growth Factor-I, [I-125] Insulin-Like Growth Factor-Ii, and [I-125] Insulin-Receptor Binding-Sites in Developing and Adult-Rat Brain. J Comp Neurol, 1993. 333(3): p. 375–97. 10.1002/cne.903330306
PubMed
DOI
Pardridge WM. Transport of Insulin-Related Peptides and Glucose across the Blood-Brain-Barrier. Ann N Y Acad Sci, 1993. 692: p. 126–37. 10.1111/j.1749-6632.1993.tb26211.x
PubMed
DOI
Lewitt MS, Boyd GW. The Role of Insulin-Like Growth Factors and Insulin-Like Growth Factor-Binding Proteins in the Nervous System. Biochem Insights, 2019. 12: p. 1–18. 10.1177/1178626419842176
PubMed
DOI
PMC
Reinhardt RR, Bondy CA. Insulin-Like Growth-Factors Cross the Blood-Brain-Barrier. Endocrinology, 1994. 135(5): p. 1753–61. 10.1210/endo.135.5.7525251
PubMed
DOI
Perdue JF, Chan JK, Thibault C, Radaj P, Mills B, Daughaday WH. The Biochemical-Characterization of Detergent-Solubilized Insulin-Like Growth Factor-II Receptors from Rat Placenta. J Biol Chem, 1983. 258(12): p. 7800–11.
PubMed
Martin-Kleiner I, Troselj KG. Mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) in carcinogenesis. Cancer Lett, 2010. 289(1): p. 11–22. 10.1016/j.canlet.2009.06.036
PubMed
DOI
Devi GR, Byrd JC, Slentz DH, MacDonald RG. An insulin-like growth factor II (IGF-II) affinity-enhancing domain localized within extracytoplasmic repeat 13 of the IGF-II/mannose 6-phosphate receptor. Mol Endocrinol, 1998. 12(11): p. 1661–72. 10.1210/mend.12.11.0192
PubMed
DOI
Subr V, Kostka L, Strohalm J, Etrych T, Ulbrich K. Synthesis of Well-Defined Semitelechelic Poly[N-(2-hydroxypropyl)methacrylamide] Polymers with Functional Group at the alpha-End of the Polymer Chain by RAFT Polymerization. Macromolecules, 2013. 46(6): p. 2100–8. 10.1021/ma400042u
DOI
Jiracek J, Zakova L. Structural Perspectives of Insulin Receptor Isoform-Selective Insulin Analogs. Front Endocrinol, 2017. 8: 167 10.3389/Fendo.2017.00167
PubMed
DOI
PMC
Zakova L, Barth T, Jiracek J, Barthova J, Zorad S. Shortened insulin analogues: Marked changes in biological activity resulting from replacement of TyrB26 and N-methylation of peptide bonds in the C-terminus of the B-chain. Biochemistry, 2004. 43(8): p. 2323–31. 10.1021/bi036001w
PubMed
DOI
Zakova L, Kazdova L, Hanclova I, Protivinska E, Sanda M, Budesinsky M, et al. Insulin analogues with modifications at position B26. Divergence of binding affinity and biological activity. Biochemistry, 2008. 47(21): p. 5858–68. 10.1021/bi702086w
PubMed
DOI
Subramanian K, Fee CJ, Fredericks R, Stubbs RS, Hayes MT. Insulin receptor-insulin interaction kinetics using multiplex surface plasmon resonance. J Mol Recognit, 2013. 26(12): p. 643–52. 10.1002/jmr.2307
PubMed
DOI
Ziegler AN, Chidambaram S, Forbes BE, Wood TL, Levison SW. Insulin- like Growth Factor- II (IGF- II) and IGF- II. Analogs with Enhanced Insulin Receptor- a Binding Affinity Promote Neural Stem Cell Expansion. J Biol Chem, 2014. 289(8): p. 4626–33. 10.1074/jbc.M113.537597
PubMed
DOI
PMC
Drejer K, Kruse V, Larsen UD, Hougaard P, Bjorn S, Gammeltoft S. Receptor-Binding and Tyrosine Kinase Activation by Insulin Analogs with Extreme Affinities Studied in Human Hepatoma Hepg2 Cells. Diabetes, 1991. 40(11): p. 1488–95. 10.2337/diab.40.11.1488
PubMed
DOI
Kurtzhals P, Schaffer L, Sorensen A, Kristensen C, Jonassen I, Schmid C, et al. Correlations of receptor binding and metabolic and mitogenic potencies of insulin analogs designed for clinical use. Diabetes, 2000. 49(6): p. 999–1005. 10.2337/diabetes.49.6.999
PubMed
DOI
Yu XW, Pandey K, Katzman AC, Alberini CM. A role for CIM6P/IGF2 receptor in memory consolidation and enhancement. Elife, 2020. 9: 10.7554/eLife.54781
PubMed
DOI
PMC