Impact of genetic polymorphisms in kinetochore and spindle assembly genes on chromosomal aberration frequency in healthy humans
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, multicentrická studie, práce podpořená grantem
PubMed
33198934
DOI
10.1016/j.mrgentox.2020.503253
PII: S1383-5718(20)30123-6
Knihovny.cz E-zdroje
- Klíčová slova
- Chromosomal aberration, Environmental toxicology, GWAS, Genetic Polymorphism, Kinetochore Function, Mitotic checkpoint,
- MeSH
- chromozomální aberace * MeSH
- chromozomální proteiny, nehistonové genetika MeSH
- cyklin B1 genetika MeSH
- cyklin-dependentní kinasy genetika MeSH
- dospělí MeSH
- frekvence genu MeSH
- jednonukleotidový polymorfismus * MeSH
- kinasa aktivující cyklin dependentní kinasy MeSH
- kinetochory metabolismus MeSH
- kohortové studie MeSH
- kontrolní body M fáze buněčného cyklu genetika MeSH
- kultivované buňky MeSH
- lidé MeSH
- lineární modely MeSH
- odds ratio MeSH
- transkripční faktory genetika MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- práce podpořená grantem MeSH
- Názvy látek
- CCNB1 protein, human MeSH Prohlížeč
- CENPH protein, human MeSH Prohlížeč
- chromozomální proteiny, nehistonové MeSH
- cyklin B1 MeSH
- cyklin-dependentní kinasy MeSH
- kinasa aktivující cyklin dependentní kinasy MeSH
- TEX14 protein, human MeSH Prohlížeč
- transkripční faktory MeSH
Genomic instability is a characteristic of a majority of human malignancies. Chromosomal instability is a common form of genomic instability that can be caused by defects in mitotic checkpoint genes. Chromosomal aberrations in peripheral blood are also indicative of genotoxic exposure and potential cancer risk. We evaluated associations between inherited genetic variants in 33 mitotic checkpoint genes and the frequency of chromosomal aberrations (CAs) in the presence and absence of environmental genotoxic exposure. Associations with both chromosome and chromatid type of aberrations were evaluated in two cohorts of healthy individuals, namely an exposed and a reference group consisting of 607 and 866 individuals, respectively. Binary logistic and linear regression analyses were performed for the association studies. Bonferroni-corrected significant p-value was 5 × 10-4 for 99 tests based on the number of analyzed genes and phenotypes. In the reference group the most prominent associations were found with variants in CCNB1, a master regulator of mitosis, and in genes involved in kinetochore function, including CENPH and TEX14, whereas in the exposed group the main association was found with variants in TTK, also an important gene in kinetochore function. How the identified variants may affect the fidelity of mitotic checkpoint remains to be investigated, however, the present study suggests that genetic variation may partly explain interindividual variation in the formation of CAs.
Department of Molecular Genetic Epidemiology German Cancer Research Center 69120 Heidelberg Germany
Department of Molecular Genetic Epidemiology German Cancer Research Center Heidelberg Germany
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