Telomere length in peripheral blood lymphocytes related to genetic variation in telomerase, prognosis and clinicopathological features in breast cancer patients
Jazyk angličtina Země Velká Británie, Anglie Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
33367858
DOI
10.1093/mutage/geaa030
PII: 6050628
Knihovny.cz E-zdroje
- MeSH
- alely MeSH
- celogenomová asociační studie MeSH
- dospělí MeSH
- genetická predispozice k nemoci genetika MeSH
- genetická variace genetika MeSH
- genotyp MeSH
- homeostáza telomer genetika MeSH
- jednonukleotidový polymorfismus genetika MeSH
- leukocyty mononukleární MeSH
- leukocyty patologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- lymfatické metastázy genetika patologie MeSH
- nádorové biomarkery genetika MeSH
- nádory prsu krev genetika patologie MeSH
- RNA genetika MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- staging nádorů MeSH
- telomerasa genetika MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- nádorové biomarkery MeSH
- RNA MeSH
- telomerasa MeSH
- telomerase RNA MeSH Prohlížeč
- TERT protein, human MeSH Prohlížeč
Disruption of telomere length (TL) homeostasis in peripheral blood lymphocytes has been previously assessed as a potential biomarker of breast cancer (BC) risk. The present study addressed the relationship between lymphocyte TL (LTL), prognosis and clinicopathological features in the BC patients since these associations are insufficiently explored at present. LTL was measured in 611 BC patients and 154 healthy controls using the monochrome multiplex quantitative Polymerase Chain Reaction assay. In addition, we genotyped nine TL-associated single-nucleotide polymorphisms that had been identified through genome-wide association studies. Our results showed that the patients had significantly (P = 0.001, Mann-Whitney U-test) longer LTL [median (interquartile range); 1.48 (1.22-1.78)] than the healthy controls [1.27 (0.97-1.82)]. Patients homozygous (CC) for the common allele of hTERT rs2736108 or the variant allele (CC) of hTERC rs16847897 had longer LTL. The latter association remained statistically significant in the recessive genetic model after the Bonferroni correction (P = 0.004, Wilcoxon two-sample test). We observed no association between LTL and overall survival or relapse-free survival of the patients. LTL did not correlate with cancer staging based on Union for International Cancer Control (UICC), The tumor node metastasis (TNM) staging system classification, tumour grade or molecular BC subtypes. Overall, we observed an association between long LTL and BC disease and an association of the hTERC rs16847897 CC genotype with increased LTL. However, no association between LTL, clinicopathological features and survival of the patients was found.
Division of Cancer Epidemiology German Cancer Research Center Im Neuenheimer Feld Heidelberg Germany
Citace poskytuje Crossref.org
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