Rapid effects of neurosteroids on neuronal plasticity and their physiological and pathological implications
Language English Country Ireland Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
33636284
DOI
10.1016/j.neulet.2021.135771
PII: S0304-3940(21)00149-X
Knihovny.cz E-resources
- Keywords
- Drug development, Ligand-gated ion channel, Neuroactive steroids, Neurosteroids, Steroid,
- MeSH
- Ligand-Gated Ion Channels metabolism MeSH
- Humans MeSH
- Neuronal Plasticity drug effects MeSH
- Neuroprotective Agents pharmacology MeSH
- Neurosteroids analogs & derivatives metabolism pharmacology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Ligand-Gated Ion Channels MeSH
- Neuroprotective Agents MeSH
- Neurosteroids MeSH
Current neuroscience research on neurosteroids and their synthetic analogues - neuroactive steroids - clearly demonstrate their drug likeness in a variety of neurological and psychiatric conditions. Moreover, research on neurosteroids continues to provide novel mechanistic insights into receptor activation or inhibition of various receptors. This mini-review will provide a high-level overview of the research area and discuss the various classes of potential physiological and pathological implications discovered so far.
References provided by Crossref.org
Corticosteroids as Selective and Effective Modulators of Glycine Receptors
Allosteric Modulation of Muscarinic Receptors by Cholesterol, Neurosteroids and Neuroactive Steroids
Steroid Sulfation in Neurodegenerative Diseases
