The novel coronavirus pandemic has rapidly spread around the world since December 2019. Various techniques have been applied in identification of SARS-CoV-2 or COVID-19 infection including computed tomography imaging, whole genome sequencing, and molecular methods such as reverse transcription polymerase chain reaction (RT-PCR). This review article discusses the diagnostic methods currently being deployed for the SARS-CoV-2 identification including optical biosensors and point-of-care diagnostics that are on the horizon. These innovative technologies may provide a more accurate, sensitive and rapid diagnosis of SARS-CoV-2 to manage the present novel coronavirus outbreak, and could be beneficial in preventing any future epidemics. Furthermore, the use of green synthesized nanomaterials in the optical biosensor devices could leads to sustainable and environmentally-friendly approaches for addressing this crisis.

Biomaterial Group Department of Biomedical Engineering Amirkabir University of Technology Tehran Iran

Cellular and Molecular Biology Research Center Shahid Beheshti University of Medical Sciences Tehran Iran

Department of Chemical Engineering Amirkabir University of Technology Tehran Iran

Department of Chemistry Sharif University of Technology Tehran Iran

Department of Materials Science and Engineering Research Institute of Advanced Materials Seoul National University Seoul 08826 Republic of Korea

Department of Medical Biotechnology School of Advanced Technologies in Medicine Shahid Beheshti University of Medical Sciences Tehran Iran

Department of Medical Nanotechnology Faculty of Advanced Technologies in Medicine Iran University of Medical Sciences Tehran Iran

Department of Pharmaceutical Nanotechnology Faculty of Pharmacy Tehran University of Medical Sciences Tehran Iran

Laser Research Centre Faculty of Health Science University of Johannesburg Doornfontein 2028 South Africa

Nanotechnology Research Centre Faculty of Pharmacy Tehran University of Medical Sciences Tehran Iran

Regional Centre of Advanced Technologies and Materials Palacky University Šlechtitelů 27 783 71 Olomouc Czech Republic

Student Research Committee Department of Medical Biotechnology School of Advanced Technologies in Medicine Shahid Beheshti University of Medical Sciences Tehran Iran

Universal Scientific Education and Research Center Tehran Iran

Université de Lorraine CentraleSupélec LMOPS F 57000 Metz France

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CaZnO-based nanoghosts for the detection of ssDNA, pCRISPR and recombinant SARS-CoV-2 spike antigen and targeted delivery of doxorubicin

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