Monitoring of circulating amino acids in patients with pancreatic cancer and cancer cachexia using capillary electrophoresis and contactless conductivity detection
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
34228371
DOI
10.1002/elps.202100174
Knihovny.cz E-zdroje
- Klíčová slova
- Branched chain amino acids, Cancer cachexia, Capillary electrophoresis, Contactless conductivity detection, Insulin,
- MeSH
- aminokyseliny * MeSH
- elektrická vodivost MeSH
- elektroforéza kapilární MeSH
- glutamin MeSH
- kachexie MeSH
- lidé MeSH
- nádory slinivky břišní * MeSH
- větvené aminokyseliny MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- aminokyseliny * MeSH
- glutamin MeSH
- větvené aminokyseliny MeSH
Branched chain amino acids (BCAAs), alanine and glutamine are determined in human plasma by capillary electrophoresis with contactless conductivity detection (CE/C4 D). The baseline separation of five amino acids from other plasma components is achieved on the short capillary effective length of 18 cm in 3.2 mol/L acetic acid with addition of 13% v/v methanol as background electrolyte. Migration times range from 2.01 min for valine to 2.84 min for glutamine, and LODs for untreated plasma are in the interval 0.7-0.9 μmol/L. Sample treatment is based on the addition of acetonitrile to only 15 μL of plasma and supernatant is directly subjected to CE/C4 D. Circulating amino acids are measured in patients with pancreatic cancer and cancer cachexia during oral glucose tolerance test. It is shown that patients with pancreatic cancer and cancer cachexia syndrome exhibit low basal circulating BCAAs and glutamine levels and loss of their insulin-dependent suppression.
3rd Faculty of Medicine Department of Hygiene Charles University Prague Czechia
Centre for the Research on Diabetes Metabolism and Nutrition 3rd Faculty of Medicine Prague Czechia
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