Transposable elements and Piwi‑interacting RNAs in hemato‑oncology with a focus on myelodysplastic syndrome (Review)
Language English Country Greece Media print-electronic
Document type Journal Article, Review
PubMed
34779490
DOI
10.3892/ijo.2021.5285
PII: 105
Knihovny.cz E-resources
- Keywords
- P‑element‑induced WImpy testis‑interacting RNAs, leukemia, myelodysplastic syndrome, transposable element,
- MeSH
- Humans MeSH
- RNA, Small Interfering genetics MeSH
- Myelodysplastic Syndromes genetics pathology MeSH
- DNA Transposable Elements * MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Names of Substances
- RNA, Small Interfering MeSH
- DNA Transposable Elements * MeSH
Our current understanding of hematopoietic stem cell differentiation and the abnormalities that lead to leukemogenesis originates from the accumulation of knowledge regarding protein‑coding genes. However, the possible impact of transposable element (TE) mobilization and the expression of P‑element‑induced WImpy testis‑interacting RNAs (piRNAs) on leukemogenesis has been beyond the scope of scientific interest to date. The expression profiles of these molecules and their importance for human health have only been characterized recently due to the rapid progress of high‑throughput sequencing technology development. In the present review, current knowledge on the expression profile and function of TEs and piRNAs was summarized, with specific focus on their reported involvement in leukemogenesis and pathogenesis of myelodysplastic syndrome.
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