Reducing misclassification of mild cognitive impairment based on base rate information from the Uniform data set
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- Keywords
- Aging, Alzheimer’s disease, Neuropsychological assessment, diagnostic criteria, mild cognitive impairment, psychometrics,
- MeSH
- Alzheimer Disease * psychology MeSH
- Cognitive Dysfunction * diagnosis MeSH
- Cognition Disorders * MeSH
- Humans MeSH
- Neuropsychological Tests MeSH
- Aged MeSH
- Check Tag
- Humans MeSH
- Aged MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
The current study aimed to define and validate the criteria for characterizing possible and probable cognitive deficits based on the psychometric approach using the Uniform data set Czech version (UDS-CZ 2.0) to reduce the rate of misdiagnosis. We computed the prevalence of low scores on the 14 subtests of UDS-CZ 2.0 in a normative sample of healthy older adults and validated criteria for possible and probable cognitive impairment on the sample of amnestic Mild Cognitive Impairment (MCI) patients. The misclassification rate of the validation sample using psychometrically derived criteria remained low: for classification as possible impairment, we found 66-76% correct classification in the clinical sample and only 2-8% false positives in the healthy control validation sample, similar results were obtained for probable cognitive impairment. Our findings offer a psychometric approach and a computational tool to minimize the misdiagnosis of mild cognitive impairment compared to traditional criteria for MCI.
Czech Academy of Sciences Institute of Psychology Praha Czech Republic
Department of Clinical Psychology Motol University Hospital Czech Republic
Department of Psychology Charles University Faculty of Arts Prague Czech Republic
International Clinical Research Centre St Anne's University Hospital Brno Brno Czech Republic
Montefiore Medical Center Bronx New York USA
National Institute of Mental Health Klecany Czech Republic
Prague College of Psychosocial Studies Prague Czech Republic
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