Impact of chronic obstructive pulmonary disease on short-term outcome in patients with ST-elevation myocardial infarction during COVID-19 pandemic: insights from the international multicenter ISACS-STEMI registry
Language English Country England, Great Britain Media electronic
Document type Journal Article, Multicenter Study
PubMed
35971173
PubMed Central
PMC9376902
DOI
10.1186/s12931-022-02128-0
PII: 10.1186/s12931-022-02128-0
Knihovny.cz E-resources
- Keywords
- COPD, Mortality, STEMI,
- MeSH
- Pulmonary Disease, Chronic Obstructive * diagnosis epidemiology therapy MeSH
- COVID-19 * epidemiology MeSH
- ST Elevation Myocardial Infarction * diagnosis epidemiology therapy MeSH
- Percutaneous Coronary Intervention * adverse effects MeSH
- Humans MeSH
- Hospital Mortality MeSH
- Pandemics MeSH
- Registries MeSH
- Retrospective Studies MeSH
- SARS-CoV-2 MeSH
- Aged MeSH
- Treatment Outcome MeSH
- Check Tag
- Humans MeSH
- Aged MeSH
- Publication type
- Journal Article MeSH
- Multicenter Study MeSH
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is projected to become the third cause of mortality worldwide. COPD shares several pathophysiological mechanisms with cardiovascular disease, especially atherosclerosis. However, no definite answers are available on the prognostic role of COPD in the setting of ST elevation myocardial infarction (STEMI), especially during COVID-19 pandemic, among patients undergoing primary angioplasty, that is therefore the aim of the current study. METHODS: In the ISACS-STEMI COVID-19 registry we included retrospectively patients with STEMI treated with primary percutaneous coronary intervention (PCI) between March and June of 2019 and 2020 from 109 high-volume primary PCI centers in 4 continents. RESULTS: A total of 15,686 patients were included in this analysis. Of them, 810 (5.2%) subjects had a COPD diagnosis. They were more often elderly and with a more pronounced cardiovascular risk profile. No preminent procedural dissimilarities were noticed except for a lower proportion of dual antiplatelet therapy at discharge among COPD patients (98.9% vs. 98.1%, P = 0.038). With regards to short-term fatal outcomes, both in-hospital and 30-days mortality occurred more frequently among COPD patients, similarly in pre-COVID-19 and COVID-19 era. However, after adjustment for main baseline differences, COPD did not result as independent predictor for in-hospital death (adjusted OR [95% CI] = 0.913[0.658-1.266], P = 0.585) nor for 30-days mortality (adjusted OR [95% CI] = 0.850 [0.620-1.164], P = 0.310). No significant differences were detected in terms of SARS-CoV-2 positivity between the two groups. CONCLUSION: This is one of the largest studies investigating characteristics and outcome of COPD patients with STEMI undergoing primary angioplasty, especially during COVID pandemic. COPD was associated with significantly higher rates of in-hospital and 30-days mortality. However, this association disappeared after adjustment for baseline characteristics. Furthermore, COPD did not significantly affect SARS-CoV-2 positivity. TRIAL REGISTRATION NUMBER: NCT04412655 (2nd June 2020).
3rd Medicine Division ASST Spedali Civili Brescia Italy
Azienda Ospedaliero Universitaria Ospedali Riuniti Trieste Trieste Italy
Cardiology Department Hospital Garcia de Orta Pragal Almada Portugal
Cardiology Division Department of Internal Medicine National Taiwan University Hospital Tapei Taiwan
Cardiology Institute Istanbul University Istanbul Turkey
Center for Cardiovascular Diseases Ohrid North Macedonia
Center Hospitalier d'Antibes Juan Les Pins Antibes France
Central Hospital of Medical University of Lodz Lodz Poland
Centre for Intensive Internal Medicine University Medical Centre Ljubljana Slovenia
Clinic Emergency Hospital of Bucharest Bucharest Romania
Complexo Hospetaliero Universitario La Coruna La Coruna Spain
Department of Cardiology ASL 4 Liguria Lavagna Italy
Department of Cardiology Hospital Bezmialem Vakıf University İstanbul Turkey
Department of Cardiology Medisch Spectrum Twente Thoraxcentrum Twente Enschede The Netherlands
Department of Cardiology National Heart Center Singapore Singapore
Department of Cardiology National University Hospital Singapore Singapore
Department of Cardiology Queen Elizabeth Hospital University of Hong Kong Yau Ma Tei Hong Kong
Department of Cardiology Queen Mary Hospital University of Hong Kong Pok Fu Lam Hong Kong
Department of Cardiology University Hospital Centre University of Zagreb Zagreb Croatia
Department of Statistical Sciences University of Padova Padua Italy
Division of Cardiology Alexandra Hospital Athens Greece
Division of Cardiology Assiut University Heart Hospital Assiut University Asyut Egypt
Division of Cardiology Attikon University Hospital Athens Greece
Division of Cardiology AUSL IRCCS Reggio Emilia Reggio Emilia Italy
Division of Cardiology Azienda Ospedaliera Ospedali Riuniti Marche Nord Pesaro Italy
Division of Cardiology Blida University Hospital Blida Algeria
Division of Cardiology Bursa City Hospital Bursa Turkey
Division of Cardiology Center Hospitalier Universitaire de Lille Lille France
Division of Cardiology CHU Lariboisière AP HP Paris 7 University INSERM UMRS 942 Paris France
Division of Cardiology Clinica Villa dei Fiori Acerra Italy
Division of Cardiology Complejo Hospitalario de Toledo Toledo Spain
Division of Cardiology Faculty of Medicine Eskisehir Osmangazi University Eskisehir Turkey
Division of Cardiology Groupe Hospitalier Mutualiste de Grenoble Grenoble France
Division of Cardiology Heart Centre Turku Turku Finland
Division of Cardiology Hopital Erasmus Universitè Libre de Bruxelles Brussels Belgium
Division of Cardiology Hospiatl Cordoba Cordoba Argentina
Division of Cardiology Hospital Cabueñes Gijon Spain
Division of Cardiology Hospital Clinico Universitario de Valencia Valencia Spain
Division of Cardiology Hospital de Santa Cruz CHLO Nova Medical School CEDOC Lisbon Portugal
Division of Cardiology Hospital de Santo António Porto Portugal
Division of Cardiology Hospital Puerta de Hierro Majadahonda Madrid Spain
Division of Cardiology Hospital Puerta del Mar Cadiz Spain
Division of Cardiology Hospital Universitario de Canarias Santa Cruz de Tenerife Spain
Division of Cardiology Kontantopoulion Hospital Athens Greece
Division of Cardiology Medical University of Silezia Katowice Poland
Division of Cardiology Northwest Clinics Alkmaar The Netherlands
Division of Cardiology Odense Universitets Hospital Odense Danemark
Division of Cardiology Ospedale A Manzoni Lecco Italy
Division of Cardiology Ospedale Civico Arnas Palermo Italy
Division of Cardiology Ospedale degli Infermi ASL Biella Ponderano Italy
Division of Cardiology Ospedale del Mare Naples Italy
Division of Cardiology Ospedale F Spaziani Frosinone Italy
Division of Cardiology Ospedale G Moscati Aversa Italy
Division of Cardiology Ospedale Maggiore Bologna Bologna Italy
Division of Cardiology Ospedale S Maurizio Bolzano Bolzano Italy
Division of Cardiology Ospedale San Giovanni di Dio e Ruggi d'Aragona Salerno Italy
Division of Cardiology Ospedale Sant'Anna Ferrara Italy
Division of Cardiology Ospedale Santa Chiara di Trento Trento Italy
Division of Cardiology Ospedale Santa Maria delle Grazie Pozzuoli Italy
Division of Cardiology Ospedale Santa Maria Goretti Latina Latina Italy
Division of Cardiology Otamendi Hospital Buenos Aires Argentina
Division of Cardiology Oulu University Hospital Oulu Finland
Division of Cardiology Radboud University Medical Center Nijmegen The Netherlands
Division of Cardiology St Antonius Hospital Nieuwegein The Netherlands
Division of Cardiology UMC Utrecht Utrecht The Netherlands
Division of Cardiology Universidad UPB Universidad CES Medellin Colombia
Division of Clinical and Experimental Cardiology AOU Sassari Sassari Italy
H Universitario y Politécnico La Fe Valencia Spain
Hospital Clínico Universitario Virgen de la Victoria Málaga Spain
Hospital Germans Triasi Pujol Badalona Spain
Instituto Cardiovascular de Buenos Aires Buenos Aires Argentina
Instituto de Cardiologia de Santa Catarina Praia Comprida São José Brasil
Instituto de Cardiologia do Rio Grande do Sul Porto Alegre Brazil
Instituto de Cardiologia Integral Montevideo Uruguay
Interventional Cardiology Unit Azienda Ospedaliera Sanitaria Parma Italy
Interventional Cardiology Unit Azienda Ospedaliero Universitaria Ospedali Riuniti Ancona Italy
Invasive Cardiology and Congenital Heart Disease Patras University Hospital Patras Greece
Iraklion University Hospital Crete Greece
Maastricht University Medical Center Maastricht The Netherlands
Tyumen Cardiology Research Center Tyumen Russia
University Hospital Brno Medical Faculty of Masaryk University Brno Czech Republic
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ClinicalTrials.gov
NCT04412655
