Is non-invasive brain stimulation effective for cognitive enhancement in Alzheimer's disease? An updated meta-analysis
Language English Country Netherlands Media print-electronic
Document type Journal Article, Meta-Analysis, Systematic Review, Research Support, Non-U.S. Gov't
PubMed
36215904
DOI
10.1016/j.clinph.2022.09.010
PII: S1388-2457(22)00897-5
Knihovny.cz E-resources
- Keywords
- Alzheimer’s disease, Brain stimulation, Dementia, MCI, Mild cognitive impairment, Noninvasive, rTMS, tDCS,
- MeSH
- Alzheimer Disease * therapy psychology MeSH
- Cognition MeSH
- Cognitive Dysfunction * therapy psychology MeSH
- Humans MeSH
- Brain physiology MeSH
- Transcranial Direct Current Stimulation * methods MeSH
- Transcranial Magnetic Stimulation methods MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Meta-Analysis MeSH
- Research Support, Non-U.S. Gov't MeSH
- Systematic Review MeSH
OBJECTIVE: Alzheimer's disease dementia (AD) and its preclinical stage, mild cognitive impairment (MCI), are critical issues confronting the aging society. Non-invasive brain stimulation (NIBS) techniques have the potential to be effective tools for enhancing cognitive functioning. The main objective of our meta-analysis was to quantify and update the status of the efficacy of repetitive Transcranial Magnetic Stimulation (rTMS) and Transcranial Direct Current Stimulation (tDCS) when applied in AD and MCI. METHODS: The systematic literature search was conducted in PubMed and Web of Science according to PRISMA statement. RESULTS: Pooled effect sizes (Hedges' g) from 32 studies were analyzed using random effect models. We found both, rTMS and tDCS to have significant immediate cognition-enhancing effect in AD with rTMS inducing also beneficial long-term effects. We found no evidence for synergistic effect of cognitive training with NIBS. CONCLUSIONS: In AD a clinical recommendation can be made for NEURO-ADTM system and for high-frequency rTMS over the left dorsolateral prefrontal cortex (DLPFC) as probably effective protocols (B-level of evidence) and for anodal tDCS over the left DLPFC as a possibly effective. SIGNIFICANCE: According to scientific literature, NIBS may be an effective method for improving cognition in AD and possibly in MCI.
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