2nd Internal Medicine Department Christian Albrechts University of Kiel and University Hospital Schleswig Holstein Kiel Germany

Central European Institute of Technology Masaryk University Brno Czech Republic

Clinical Research Unit CATCH ALL Bonn Germany

Department of Medicine 2 Hematology Oncology Goethe University Hospital Frankfurt M Germany

University Cancer Center Schleswig Holstein University Hospital Schleswig Holstein Kiel and Lübeck Germany

Zobrazit více v PubMed

Zhang Z, Burrows PD, Cooper MD. The molecular basis and biological significance of VH replacement. Immunol Rev. 2004;197:231–242. PubMed

Morgan D, Tergaonkar V. Unraveling B cell trajectories at single cell resolution. Trends Immunol. 2022;43:210–229. PubMed

Beishuizen A, Hählen K, Hagemeijer A, et al. . Multiple rearranged immunoglobulin genes in childhood acute lymphoblastic leukemia of precursor B-cell. Leukemia. 1991;5:657–667. PubMed

Choi Y, Greenberg SJ, Du TL, et al. . Clonal evolution in B-lineage acute lymphoblastic leukemia by contemporaneous VH-VH gene replacements and VH-DJH gene rearrangements. Blood. 1996;87:2506–2512. PubMed

Gawad C, Pepin F, Carlton VEH, et al. . Massive evolution of the immunoglobulin heavy chain locus in children with B precursor acute lymphoblastic leukemia. Blood. 2012;120:4407–4417. PubMed PMC

Bardini M, Woll PS, Corral L, et al. . Clonal variegation and dynamic competition of leukemia-initiating cells in infant acute lymphoblastic leukemia with MLL rearrangement. Leukemia. 2014;29:38–50. PubMed

Khabirova E, Jardine L, Coorens THH, et al. . Single-cell transcriptomics reveals a distinct developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic leukemia. Nat Med. 2022;28:743–751. PubMed PMC

Chen C, Yu W, Alikarami F, et al. . Single-cell multiomics reveals increased plasticity, resistant populations, and stem-cell-like blasts in KMT2A-rearranged leukemia. Blood. 2022;139:2198–2211. PubMed PMC

Bastian L, Hartmann AM, Beder T, et al. . UBTF::ATXN7L3 gene fusion defines novel B cell precursor ALL subtype with CDX2 expression and need for intensified treatment. Leukemia. 2022;36:1676–1680. PubMed PMC

Knecht H, Reigl T, Kotrová M, et al. ; EuroClonality-NGS Working Group. Quality control and quantification in IG/TR next-generation sequencing marker identification: protocols and bioinformatic functionalities by EuroClonality-NGS. Leukemia. 2019;33:2254–2265. PubMed PMC

Bystry V, Reigl T, Krejci A, et al. ; EuroClonality-NGS. ARResT/Interrogate: an interactive immunoprofiler for IG/TR NGS data. Bioinformatics. 2017;33:435–437. PubMed

Schafernak KT, Williams JA, Clyde BI, et al. . Identification of KMT2A-ARHGEF12 fusion in a child with a high-grade B-cell lymphoma. Cancer Genet. 2021;258:23–26. PubMed

Liu J, Lange MD, Hong SY, et al. . Regulation of VH replacement by B cell receptor–mediated signaling in human immature B cells. J Immunol. 2013;190:5559–5566. PubMed PMC

Roy A, Bystry V, Bohn G, et al. . High resolution IgH repertoire analysis reveals fetal liver as the likely origin of life-long, innate B lymphopoiesis in humans. Clin Immunol. 2017;183:8–16. PubMed PMC

Schroeder HW, Wang JY. Preferential utilization of conserved immunoglobulin heavy chain variable gene segments during human fetal life. Proc Natl Acad Sci USA. 1990;87:6146–6150. PubMed PMC

Insights into IGH clonal evolution in BCP-ALL: frequency, mechanisms, associations, and diagnostic implications