MOTIVATION: The study of immunoglobulins and T cell receptors using next-generation sequencing has finally allowed exploring immune repertoires and responses in their immense variability and complexity. Unsurprisingly, their analysis and interpretation is a highly convoluted task. RESULTS: We thus implemented ARResT/Interrogate, a web-based, interactive application. It can organize and filter large amounts of immunogenetic data by numerous criteria, calculate several relevant statistics, and present results in the form of multiple interconnected visualizations. AVAILABILITY AND IMPLEMENTATION: ARResT/Interrogate is implemented primarily in R, and is freely available at http://bat.infspire.org/arrest/interrogate/ CONTACT: nikos.darzentas@gmail.com SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

CEITEC Central European Institute of Technology Masaryk University Brno Czech Republic

Centro Ricerca Tettamanti Clinica Pediatrica Università di Milano Bicocca Ospedale San Gerardo Fondazione MBBM Monza Italy

Department of Hematology Hopital Pitié Salpêtrière and Pierre et Marie Curie University Paris France

Department of Hematology University Hospital Schleswig Holstein Campus Kiel Kiel Germany

Department of Immunology Erasmus MC University Medical Center Rotterdam The Netherlands

Department of Medicine 5 University Hospital Heidelberg Heidelberg Germany

Department of Pathology Radboud University Nijmegen Medical Center Nijmegen The Netherlands

RECAMO Masaryk Memorial Cancer Institute Brno Czech Republic

Citace poskytuje Crossref.org

Comprehensive genetic analysis by targeted sequencing identifies risk factors and predicts patient outcome in Mantle Cell Lymphoma: results from the EU-MCL network trials

Insights into IGH clonal evolution in BCP-ALL: frequency, mechanisms, associations, and diagnostic implications

NGS better discriminates true MRD positivity for the risk stratification of childhood ALL treated on an MRD-based protocol

IGH Rearrangement Evolution in Adult KMT2A-rearranged B-cell Precursor ALL: Implications for Cell-of-origin and MRD Monitoring

Quality Control for IG /TR Marker Identification and MRD Analysis

Consistent B Cell Receptor Immunoglobulin Features Between Siblings in Familial Chronic Lymphocytic Leukemia

Potential and pitfalls of whole transcriptome-based immunogenetic marker identification in acute lymphoblastic leukemia; a EuroMRD and EuroClonality-NGS Working Group study

Topology and expressed repertoire of the Felis catus T cell receptor loci

Standardized next-generation sequencing of immunoglobulin and T-cell receptor gene recombinations for MRD marker identification in acute lymphoblastic leukaemia; a EuroClonality-NGS validation study

Next-generation sequencing of immunoglobulin gene rearrangements for clonality assessment: a technical feasibility study by EuroClonality-NGS

Quality control and quantification in IG/TR next-generation sequencing marker identification: protocols and bioinformatic functionalities by EuroClonality-NGS

High resolution IgH repertoire analysis reveals fetal liver as the likely origin of life-long, innate B lymphopoiesis in humans

Is Next-Generation Sequencing the way to go for Residual Disease Monitoring in Acute Lymphoblastic Leukemia?