Therapeutic potential and limitations of curcumin as antimetastatic agent
Language English Country France Media print-electronic
Document type Journal Article, Review
PubMed
37141738
DOI
10.1016/j.biopha.2023.114758
PII: S0753-3322(23)00547-4
Knihovny.cz E-resources
- Keywords
- Curcumin, Metastasis, Migrastatic agents, Nanoparticles, Tumour targeting,
- MeSH
- Curcumin * pharmacology therapeutic use MeSH
- Humans MeSH
- Neoplasms * drug therapy MeSH
- Antineoplastic Agents * pharmacology therapeutic use chemistry MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Names of Substances
- Curcumin * MeSH
- Antineoplastic Agents * MeSH
Treatment of metastatic cancer is one of the biggest challenges in anticancer therapy. Curcumin is interesting nature polyphenolic compound with unique biological and medicinal effects, including repression of metastases. High impact studies imply that curcumin can modulate the immune system, independently target various metastatic signalling pathways, and repress migration and invasiveness of cancer cells. This review discusses the potential of curcumin as an antimetastatic agent and describes potential mechanisms of its antimetastatic activity. In addition, possible strategies (curcumin formulation, optimization of the method of administration and modification of its structure motif) to overcome its limitation such as low solubility and bioactivity are also presented. These strategies are discussed in the context of clinical trials and relevant biological studies.
References provided by Crossref.org
Curcumin: A Potential Weapon in the Prevention and Treatment of Head and Neck Cancer
Investigating antibacterial and anti-inflammatory properties of synthetic curcuminoids
Cyanine dyes in the mitochondria-targeting photodynamic and photothermal therapy
