OBJECTIVE: This study purposed to evaluate preoperative two tumor markers, namely, carcinoembryonic antigen and carbohydrate antigen (CA)19-9, in colorectal cancer for anatomotopographic location with disease stage and to assess their utility for diagnostic staging purposes. METHODS: The study retrospectively incorporated patients who had undergone surgery for colorectal cancer at our department in 2015-2018 and in whom carcinoembryonic antigen and CA19-9 tumor markers had been preoperatively analyzed. The obtained data were then statistically processed using R-project. RESULTS: A total of 155 patients had been incorporated, of whom 96 (62%) were men and 59 (38%) were women. Rectum was the most common location (74 patients, 48%), and the least represented stage was IV (18, 12%). The marker carcinoembryonic antigen was obtained in all 155 cases, while CA19-9 was in 105. The median carcinoembryonic antigen was 3 (0.34-1104.25), and the median CA19-9 was 12 (0.18-840.00). A significance was recognized between median carcinoembryonic antigen and disease stage (p-value=0.016), with stages I, II, and III (medians 2, 3, and 2) different from stage IV (median 13), while no significance for CA19-9 was recognized (p-value=0.343). No significance between either marker and location (carcinoembryonic antigen: p=0.276; CA19-9: p=0.505) was detected. The testing was performed at a significance level of alpha=0.05. CONCLUSION: This study revealed a significance between the marker carcinoembryonic antigen, but not CA19-9, and the disease stage, while no relationship of either of these markers with tumor location was found. Herewith, the study confirmed that higher carcinoembryonic antigen values may suggest the finding of more advanced forms of colorectal cancer and thus a worse prognosis of this malignant phenomenon.

Giresun University Faculty of Medicine Department of General Surgery Giresun Turkey

Giresun University Faculty of Medicine Department of Pathology Giresun Turkey

Giresun University Faculty of Medicine Division of Endocrine Surgery Giresun Turkey

Palacký University in Olomouc Faculty of Medicine Centre for Science and Research Olomouc Czech Republic

Silesian Hospital in Opava Department of Surgery Opava Czech Republic

Tomas Bata University in Zlin Faculty of Humanities Zlin Czech Republic

University Hospital Olomouc 1st Department of Surgery Olomouc Czech Republic

University of Ostrava Department of Epidemiology and Public Health Ostrava Czech Republic

University of Ostrava Faculty of Medicine Department of Surgery Ostrava Czech Republic

VŠB TUO Technical University of Ostrava Faculty of Electrotechniques and Informatics Department of Applied Mathematics Ostrava Czech Republic

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