T1 mapping of myocardium in rats using self-gated golden-angle acquisition
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
37811699
DOI
10.1002/mrm.29846
Knihovny.cz E-resources
- Keywords
- MRI, T1, cardiac, fibrosis, quantification, remodeling, retrospective gating,
- MeSH
- Phantoms, Imaging MeSH
- Rats MeSH
- Magnetic Resonance Imaging methods MeSH
- Myocardium * MeSH
- Image Processing, Computer-Assisted methods MeSH
- Reproducibility of Results MeSH
- Imaging, Three-Dimensional * methods MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
PURPOSE: The aim of this study is to design a method of myocardial T1 quantification in small laboratory animals and to investigate the effects of spatiotemporal regularization and the needed acquisition duration. METHODS: We propose a compressed-sensing approach to T1 quantification based on self-gated inversion-recovery radial two/three-dimensional (2D/3D) golden-angle stack-of-stars acquisition with image reconstruction performed using total-variation spatiotemporal regularization. The method was tested on a phantom and on a healthy rat, as well as on rats in a small myocardium-remodeling study. RESULTS: The results showed a good match of the T1 estimates with the results obtained using the ground-truth method on a phantom and with the literature values for rats myocardium. The proposed 2D and 3D methods showed significant differences between normal and remodeling myocardium groups for acquisition lengths down to approximately 5 and 15 min, respectively. CONCLUSIONS: A new 2D and 3D method for quantification of myocardial T1 in rats was proposed. We have shown the capability of both techniques to distinguish between normal and remodeling myocardial tissue. We have shown the effects of image-reconstruction regularization weights and acquisition length on the T1 estimates.
Department of Pharmacology Faculty of Medicine Masaryk University Brno Czechia
Department of Physiology Masaryk University Faculty of Medicine Brno Czechia
Faculty of Electrical Engineering and Communication Brno University of Technology Brno Czechia
Institute of Scientific Instruments Czech Academy of Sciences Brno Czechia
School of Medicine University of Utah Salt Lake City Utah USA
Viterbi School of Engineering University of Southern California Los Angeles California USA
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