Tick-borne encephalitis (TBE) is a neuroviral disease that ranges in severity from a mild febrile illness to a severe and life-threatening meningoencephalitis or encephalomyelitis. There is increasing evidence that susceptibility to tick-borne encephalitis virus (TBEV)-induced disease and its severity are largely influenced by host genetic factors, in addition to other virus- and host-related factors. In this study, we investigated the contribution of selected single nucleotide polymorphisms (SNPs) in innate immunity genes to predisposition to TBE in humans. More specifically, we investigated a possible association between SNPs rs304478 and rs303212 in the gene Interferon Induced Protein With Tetratricopeptide Repeats 1 (IFIT1), rs7070001 and rs4934470 in the gene Interferon Induced Protein With Tetratricopeptide Repeats 2 (IFIT2), and RIG-I (Retinoic acid-inducible gene I) encoding gene DDX58 rs311795343, rs10813831, rs17217280 and rs3739674 SNPs with predisposition to TBE in population of the Czech Republic, where TBEV is highly endemic. Genotypic and allelic frequencies for these SNPs were analyzed in 247 nonimmunized TBE patients and compared with 204 control subjects. The analysis showed an association of IFIT1 rs304478 SNP and DDX58 rs3739674 and rs17217280 SNPs with predisposition to TBE in the Czech population indicating novel risk factors for clinical TBE but not for disease severity. These results also highlight the role of innate immunity genes in TBE pathogenesis.

Department of Children's Infectious Disease Faculty of Medicine and University Hospital Masaryk University CZ 61300 Brno Czechia

Department of Experimental Biology Faculty of Science Masaryk University CZ 62500 Brno Czechia

Department of Infectious Diseases and Preventive Medicine Veterinary Research Institute CZ 62100 Brno Czechia

Department of Infectious Diseases University Hospital Brno and Faculty of Medicine Masaryk University CZ 62500 Brno Czechia

Federal Research Center Institute of Cytology and Genetics Siberian Branch Russian Academy of Sciences 10 Lavrentyeva Ave Novosibirsk 630090 Russia

Institute of Parasitology Biology Centre of the Czech Academy of Sciences CZ 37005 Ceske Budejovice Czechia

Joint Faculty of Veterinary Medicine Yamaguchi University Yamaguchi City Japan

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