OBJECTIVE: To compare parameters of glycemic control among three types of hybrid closed loop (HCL) systems in children with T1D (CwD) using population-wide data from the national pediatric diabetes registry ČENDA. METHODS: CwD aged <19 years treated with Medtronic MiniMed 780G (780G), Tandem t:slim X2 (Control-IQ) or do-it-yourself AndroidAPS (AAPS) systems for >12 months and monitored by CGM >70% of the time were included. HbA1c, times in glycemic ranges, and Glycemia Risk Index (GRI) were used for cross-sectional comparison between the HCL systems. RESULTS: Data from 512 CwD were analyzed. 780G, Control-IQ and AAPS were used by 217 (42.4%), 211 (41.2%), and 84 (16.4%) CwD, respectively. The lowest HbA1c value was observed in the AAPS group (44 mmol/mol; IQR 8.0, p<0.0001 vs any other group), followed by Control-IQ and 780G groups (48 (IQR 11) and 52 (IQR 10) mmol/mol, respectively). All of the systems met the recommended criteria for time in range (78% in AAPS, 76% in 780G, and 75% in Control-IQ users). CwD using AAPS spent significantly more time in hypoglycemia (5% vs 2% in 780G and 3% in Control-IQ) and scored the highest GRI (32, IQR 17). The lowest GRI (27, IQR 15) was seen in 780G users. CONCLUSION: Although all HCL systems proved effective in maintaining recommended long-term glycemic control, we observed differences that illustrate strengths and weaknesses of particular systems. Our findings could help in individualizing the choice of HCL systems.

1st Faculty of Medicine Charles University Prague Czechia

Department of Pediatrics Hospital Ceske Budejovice Ceske Budejovice Czechia

Department of Pediatrics Masaryk Hospital Usti nad Labem Czechia

Department of Pediatrics Motol University Hospital and 2nd Faculty of Medicine Prague Czechia

Department of Pediatrics University Hospital Brno Brno Czechia

Department of Pediatrics University Hospital Hradec Kralove Hradec Kralove Czechia

Department of Pediatrics University Hospital Kralovske Vinohrady Prague Czechia

Department of Pediatrics University Hospital Olomouc Olomouc Czechia

Department of Pediatrics University Hospital Ostrava Ostrava Czechia

Department of Pediatrics University Hospital Plzen Plzen Czechia

Department of Probability and Mathematical Statistics Faculty of Mathematics and Physics Charles University Prague Czechia

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