Redox Status of Erythrocytes as an Important Factor in Eryptosis and Erythronecroptosis
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články
Grantová podpora
PRIMUS/17/ MED/9
Univerzita Karlova v Praze
UNCE/MED/016
Univerzita Karlova v Praze
PubMed
38410969
DOI
10.14712/fb2023069040116
PII: fb_2023069040116
Knihovny.cz E-zdroje
- Klíčová slova
- DAMPs, RCD, ROS, apoptosis, damage-associated molecular patterns, eryptosis, erythrocytes, erythronecroptosis, hydrogen peroxide, necroptosis, reactive oxygen species, regulated cell death,
- MeSH
- eryptóza * fyziologie MeSH
- erytrocyty metabolismus MeSH
- lidé MeSH
- oxidace-redukce MeSH
- reaktivní formy kyslíku metabolismus MeSH
- vápník metabolismus MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- reaktivní formy kyslíku MeSH
- vápník MeSH
Overall, reactive oxygen species (ROS) signalling significantly contributes to initiation and mo-dulation of multiple regulated cell death (RCD) pathways. Lately, more information has become available about RCD modalities of erythrocytes, including the role of ROS. ROS accumulation has therefore been increasingly recognized as a critical factor involved in eryptosis (apoptosis of erythrocytes) and erythro-necroptosis (necroptosis of erythrocytes). Eryptosis is a Ca2+-dependent apoptosis-like RCD of erythrocytes that occurs in response to oxidative stress, hyperosmolarity, ATP depletion, and a wide range of xenobiotics. Moreover, eryptosis seems to be involved in the pathogenesis of multiple human diseases and pathological processes. Several studies have reported that erythrocytes can also undergo necroptosis, a lytic RIPK1/RIPK3/MLKL-mediated RCD. As an example, erythronecroptosis can occur in response to CD59-specific pore-forming toxins. We have systematically summarized available studies regarding the involvement of ROS and oxidative stress in these two distinct RCDs of erythrocytes. We have focused specifically on cellular signalling pathways involved in ROS-mediated cell death decisions in erythrocytes. Furthermore, we have summarized dysregulation of related erythrocytic antioxidant defence systems. The general concept of the ROS role in eryptotic and necroptotic cell death pathways in erythrocytes seems to be established. However, further studies are required to uncover the complex role of ROS in the crosstalk and interplay between the survival and RCDs of erythrocytes.
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